José Pinheiro received his Ph.D. in Statistics from the Department of Statistics at the University of Wisconsin -- Madison in 1994, with a dissertation on theory, methods and software for linear and nonlinear mixed-effects models. Afterwards, he worked for two years in the Department of Biostatistics at the same university, being involved in the design and analysis of clinical trials, as well as in research in the area of group sequential designs, in collaboration with Prof. David DeMets. In 1996 he joined the Statistics Research department at Bell Labs, as a Member of Technical Staff. During his five years at Bell Labs, he developed methods and algorithms for telecom applications which resulted in several company patents, while continuing his research in methods and software for mixed-effects models.
José moved to Novartis Pharmaceuticals in 2001, joining the Methodology group in the Biostatistics & Statistical Reporting department, and currently heads the group in the U.S. At Novartis, he has been involved in methodological development and consulting activities in various areas of biostatistics applied to drug development, including dose-finding trials, proof-of-concept studies, pharmacokinetics and pharmacodynamics models, randomization schemes, and longitudinal data analysis. For his contributions to the company, he received a Novartis Leading Scientist Award in 2006.
José is co-leader of the PhRMA working group on Adaptive Dose-Ranging Designs and a member of the PhRMA WG on Novel Adaptive Designs. He is a member of the Biostatistics and Data Management Technical Group at PhRMA, and the secretary of ENAR. José is a co-developer, with Prof. Douglas Bates, of the NLME software in S-PLUS and R for fitting and analyzing linear and non-linear mixed-effects models. They have also co-authored the book "Mixed-Effects Models in S and S-PLUS", published by Springer-Verlag in 2000, a standard reference in the area.