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January 21, 2009
Healthcare Modeling Part 2:  Simulation Modeling in Clinical Trial Design
Speaker for this event: 
  • Peter Alperin, M.D., Medical Director, Archimedes  Learn More
  • Healthcare Modeling Part 2: Simulation Modeling in Clinical Trial Design

    In this webinar Peter Alperin, M.D., Medical Director at Archimedes, Inc., will explain the Archimedes Model and its importance in defining inclusion and exclusion criteria to lower the risk of failure in clinical trials.


    The Model can be used to perform a wide variety of sensitivity analysis to understand the effects of changes in enrollment criteria for trials.  This information can by used to inform critical decisions during clinical trial design.


    The topics covered will be

    • The Archimedes Model: What is it and how does it Work?
    • Case Study: How could I use a simulation model to inform the design of a trial in cardiovascular disease and/or diabetes?

    This webinar is part of a series on Healthcare Modeling


    For more information about Part 1 - On Demand Archive available
    November 19/08
    What If Patients Listened to Their Doctors?
    To register for Part 2 - On Demand Archive available
    January 21/09
    Simulation Modeling in Clinical Trial Design
    For more information about Part 3 - On Demand Archive available
    September 22/09
    Cost Effectiveness Analysis of Personalized Medicine
    For more information about Part 4 - On Demand Archive available
    February 11/10
    How the Archimedes Model Works and is Validated
    For more information about Part 5 - On Demand Archive available
    October 6/10
    How the Archimedes Model Works - Derivation of Equations
    • Chief Executives
    • VPs, Directors of Marketing, Project Management, Strategic Planning
    • VPs of Finance
    • Medical Directors
    • Directors of Health Outcomes
    • Portfolio Managers
    • Product and Product Lifecycle Managers
    • Analysts

    for Pharmaceutical Companies and Medical Device Manufacturers


    Peter Alperin, M.D., Medical Director, Archimedes  

    Peter Alperin, MD is Medical Director at Archimedes.  His primary responsibilities include managing client engagements as well as ensuring that the Model grows to include the most relevant topics challenging healthcare.  He also is intimately involved in Archimedes product development.  In his role he ensures that the model is focused on the key aspects of a client’s questions and serves as a direct link between the client and the Archimedes scientific staff. Peter has over 14 years of healthcare experience including work in software development and informatics.  He still sees patients and is an Assistant Clinical Professor of Medicine at UCSF.  Peter has a BA in Biochemistry from UC Berkeley, where he graduated summa cum laude and Phi Beta Kappa. He received his MD degree from Southwestern Medical School where he was an AOA graduate.


    Archimedes is a Healthcare Modeling company that has built a large scale simulation model of physiology, disease, interventions, and healthcare systems.


    The Model is written at a high level of detail using object-oriented programming and run on a distributed computing network. The core of the Model is a set of ordinary and differential equations that represent the physiological pathways pertinent to diseases and their complications. The Model includes aspects of diseases and healthcare systems needed to analyze downstream clinical events, utilization, and costs including: signs and symptoms; patient behaviors in seeking care; patient encounters with the health care system (e.g. emergency room visits, office visits, and admissions); protocols and guidelines; tests and treatments; provider behaviors and performance; patient adherence to treatment recommendations; and clinical events that affect logistics, utilization, and financial costs. The Model is flexible, validated against more than 50 clinical trials, and helps decision makers understand the likely outcomes of interventions.


    To learn more about the Archimedes Model visit www.archimedesmodel.com/modeling


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