Senior Process Development Associate – ePD

Poseida

Posted on: November 23, 2021

Closing: December 23, 2021

Salary: Undisclosed

Position Type: Full Time

Job Description

Poseida is seeking a motivated and collaborative individual to join our growing Early Process Development team. This position is highly cross-functional and will work closely with Research and Development, Manufacturing Science and Technology, and Analytical Development teams to develop, optimize, and integrate next generation processes and technologies for CAR-T cell manufacturing. This is a hands-on, laboratory-based role where the individual will contribute to researching, developing, and implementing new methods and technologies to improve CAR-T production as well as product characterization. He/she will be expected to complete scientific and technical tasks on aggressive timelines. This position requires excellent communication skills with a proven ability to carry out laboratory work independently, troubleshoot technical issues, and work with automation instrumentation and software.

Responsibilities

These may include but are not limited to:

  • Participate in technology transfer from R&D teams to Early Process Development and from Early Process Development to internal and/or external manufacturing teams
  • Work with R&D teams to gain deeper understanding of process challenges and process-to-process product quality attribute variability
  • Evaluate alternative technologies to create robust, reproducible, and scalable next generation CAR-T manufacturing processes
  • Independently design and execute process development and product characterization studies. Experience with Design of Experiment (DoE) a plus
  • Develop CAR-T manufacturing platforms and assess platform suitability across cell therapy programs
  • Ex vivo analysis of CAR-T products to assess efficacy and phenotype using flow cytometry
  • Analyze and present results in team and cross-functional meetings
  • Document laboratory procedures and experiments with great attention to detail in laboratory notebooks
Requirements

Requirements, Knowledge, Skills and Abilities:

  • Bachelor’s or Master’s degree in a scientific discipline (chemistry, biology, immunology or related field) with 5 plus years of relevant experience in research or industrial laboratory.
  • Demonstrated excellent aseptic technique and suspension cell culture proficiency
  • Experience with cell separation, cell processing, cell culture, expansion, and manipulation of T cells
  • Hands-on experience in performing assays using human whole blood, PBMCs and/or purified T cell, such as multi-color immuno-phenotyping and lymphocyte subset characterization using flow cytometry, functional analysis of immune cells such as cytotoxicity and ELISA
  • Ability to work on multiple projects at once with demonstrated ability to troubleshoot, optimize and solve challenging research problems
  • Must be an organized and detail-oriented person with excellent verbal and written communications skills
  • Adequate understanding and knowledge of immunology and CAR-T cell therapy
  • Experience in several of the following areas preferred: CAR-T cell therapy, product development, process characterization, scale-up, cGMP clinical manufacturing, cell separation by magnetic beads, automation, Design of Experiment (DOE), and/or technology transfer

Poseida

Posted on: November 23, 2021

Closing: December 23, 2021

Salary($): Undisclosed

Position Type: Full Time

Career Focus: Biology, Chemistry, Immunology

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