Senior Scientist II, Chemistry and Protein Conjugation

Vir Biotechnology

Posted on: September 13, 2023

Closing: October 13, 2023

Salary: Undisclosed

Position Type: Full Time

Job Description

Vir Biotechnology is a commercial-stage immunology company focused on combining immunologic insights with cutting-edge technologies to treat and prevent serious infectious diseases. Vir has assembled four technology platforms that are designed to stimulate and enhance the immune system by exploiting critical observations of natural immune processes. Its current development pipeline consists of product candidates targeting COVID-19, hepatitis B and hepatitis D viruses, influenza A and human immunodeficiency virus.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company passionate about equality, inclusion, and respect. When everyone feels supported and encouraged to give their best, we will collectively deliver outstanding results. We are proud to have been ranked the fastest-growing company in North America on the 2022 Deloitte Technology Fast 500™.

Vir Bio is seeking a senior level chemist with a strong, hands-on background in Chemistry and protein conjugation to join our research team.  You will play a critical role in expanding Vir’s platform technologies with a specific focus on antibody drug conjugates that will span discovery research through clinical development. You will help shape our protein conjugation and chemistry strategies and will play a critical role in leveraging the Company’s antibody platform into best-in-class products for infectious diseases and other therapeutic areas. You will report to the Director, Protein Chemistry Structural Biology and collaborate extensively with all research functions. This role will be located at our San Francisco Lab facility.



  • You will design small molecules for lead discovery and optimization with a focus on intermediates for antibody drug conjugates
  • You will manage outsourced medicinal chemistry groups to create and execute chemical syntheses
  • Create and perform conjugations between proteins and small molecules, in collaboration with in-house protein chemistry team
  • Analyze complex data sets to create testable design hypotheses to advance project goals
  • You will be a chemistry and/or protein conjugation subject matter expert for internal project teams as well as external engagements with CROs/CMOs and collaborators
  • Prepare scientific reports for internal and external communications, including intellectual property filings

Qualifications and Experience:

  • PhD in Chemistry or related discipline and 7+ years related industry experience or equivalent education/experience
  • Experience with organic and synthetic chemistry
  • Extensive hands-on experience with several synthetic methodologies, method development, instrument troubleshooting, quality control and process analysis
  • Experience with generation, optimization and characterization of antibody-drug conjugates is of particular interest
  • Experience managing outsourced full-time small molecule chemistry groups
  • Demonstrated leadership in chemistry and/or protein conjugation as documented by scientific accomplishments and strong publication record
  • Hands-on experience with antibodies/proteins is a plus
  • Familiarity with biophysical methods is preferred
  • Demonstrated ability to build and manage successful relationships with internal research teams
  • Excellent communication skills, logical and analytical thinking, ability to multitask, collaborate , work independently and the ability to learn, and problem solve


Vir’s compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes: compensation, bonus and equity as well as many other Vir benefits and perks such as: health, dental, vision, life and disability insurance benefits, non-accrual paid time off, company shut down for holidays, commuter benefits, child care reimbursement, education reimbursement, 401K match and lunch for all lab essential personnel!

Vir is an equal opportunity employer.  We value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment. Please contact Human Resources to request accommodation.

Vir Biotechnology

Posted on: September 13, 2023

Closing: October 13, 2023

Salary($): Undisclosed

Position Type: Full Time

Career Focus: Analyst, Chemistry, Scientist

Similar Jobs

Anywhere, Washington, United States

Mid Level FDA Regulatory Associate/Specialist

The Mid Level FDA Regulatory Associate/Specialist will support the VP, L...

Anywhere, Canada

Sr. Patent Scientist, Medicinal Chemistry

The Sr. Patent Scientist will have the ability to grasp new technical te...

Anywhere, United States

Senior Medical Director, Medical Affairs

ImmunityBio, Inc. is a late-stage immunotherapy company developing next-...

San Diego, United States

Senior Research Associate, Analytical Development

ImmunityBio, Inc. is a late-stage immunotherapy company developing next-...