Osmolality is described as the measurement of the contribution of all the dissolved solutes to the osmotic pressure of a solution. In BioPharma, osmolality is usually used as a quality control checkpoint for cell culture media, formulation buffers or formulated drug products.
In this webinar, the featured speakers share how they use osmolality as a quality control tool, similar to the routine application in the biopharma industry. In addition, osmolality is applied as an experimental measurement to correlate with IgG production, nutrient depletion studies and bioprocessing applications.
This webinar will describe the impact of osmolality assessment in correlation with IgG production when examining the effect of plant protein hydrolysates as additives, in a media development project. When examining the effect of changing media composition on IgG glycosylation in this project, osmolality was tracked and correlated with growth and productivity. Osmolality measurements were utilised to correlate the suitability of culture conditions in ‘re-fed’ media vs. controls of complete media during the investigation into the recoverability of cells at various stages of nutrient depletion. These preliminary investigations are currently in the process of being scaled up to bioreactor level (bench scale) where osmolality validation will be used on samples collected at line process analytical technology (PAT) instrumentation development.
Discover how osmolality is utilized as a quality control tool in biopharmaceutical development, including its correlation with IgG production and nutrient depletion studies, in this informative webinar.
Sandra Roche, PhD, Senior Scientist, Cell Technology Group, National Institute for Bioprocessing Research and Training (NIBRT)
Shweta Nair, Senior Product Manager, Biopharma, Advanced Instruments, LLC.
Shweta Nair is the Senior Product Manager of the Biotech Portfolio of Osmometers at Advanced Instruments. With over a decade of experience in the biotech industry, Shweta has been at Advanced Instruments for three years, driving the GMP and data compliance of the osmometer portfolio. Prior to Advanced Instruments, Shweta was the Global product manager at Millipore Sigma managing lab equipment portfolio for biopharmaceutical and research markets.
Who Should Attend?
- Cell Line Development/Therapeutic Antibody Production Scientists and Managers
- Cell Therapy/Cell Therapy Production Scientists and Managers
- Media Development & Media related positions
- Senior Scientists/Scientists
- Process Engineers
- Process Development Managers/Directors
- Process Subject-Matter Experts
- Group leaders
What You Will Learn
Attendees will learn:
- How to implement osmolality as more than just a quality control tool in upstream processes —specifically, how to utilize osmolality testing for an assessment of IgG production in media development when examining the effect of plant protein hydrolysates as additives
- About the biotech osmometer portfolio currently on offer to help improve workflow efficiency in the upstream space
Advanced Instruments is a global company offering novel portfolios of analytical tools across bioprocessing including Solentim ®, a portfolio of best-in-class technologies which enable clonal isolation, outgrowth, and characterization in workflows and assurance of clonality for regulatory bodies. It’s OsmoTECH ® portfolio includes a robust line of micro-osmometers designed to support bioprocessing and quality control (QC), and the newest addition, Artel ® brings industry-leading solutions to validate, automate, and calibrate liquid handling processes and instrumentation.
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