Cost-Efficient and Green Manufacturing of Peptides Thanks to Molecular Hiving Technology

Bachem and Jitsubo CO., LTD. recently announced the signature of an exclusive Licensing Agreement for Jitsubo’s Molecular Hiving™ technology. Under the License agreement, Jitsubo will develop selected manufacturing processes using their Molecular Hiving technology and transfer these processes to Bachem. Bachem will further optimize, scale up and produce for commercial applications.

Molecular Hiving is a tag-assisted liquid-phase peptide synthesis technology developed by Professor Kazuhiro Chiba at Tokyo University of Agriculture and Technology. This technology uses a hydrophobic tag, which is applied in the same way as the resin for solid-phase peptide synthesis (SPPS) processes.

The same standard Fmoc amino acid derivatives as for SPPS are applied for assembling the peptide chain. However, all couplings and cleavages of the Fmoc protecting group are performed in solution allowing for fast reactions and direct in-process controls, e.g. by HPLC. Excess reagents as well as coupling and cleavage related by-products are solely removed by aqueous extractions. Therefore, intermediate isolation of the tag-bound peptide and excessive washing steps are not required for Molecular Hiving™ technology.

In this webinar, the speaker will guide attendees through the individual steps for synthesis of peptides applying Molecular Hiving™ technology. Webinar attendees will learn about the scalability and the substantial advantages of this technology regarding efficiency and towards greener manufacturing, as solvent consumption and material requirements are significantly reduced compared to conventional SPPS processes. Molecular Hiving™ also allows the synthesis of peptides without the use of solvents and reagents which are carcinogenic, mutagenic, or toxic to reproduction (CMR substances). This makes peptide products manufactured by this technology highly attractive for the pharmaceutical and cosmetics industry.

Speaker

Dr. Wolfgang Seufert, Director Production III – Process Development, Bachem

Dr. Wolfgang Seufert is leading a process development team within the Production department at Bachem AG. Having joined Bachem more than 12 years ago and working in several positions at the Bubendorf and Torrance sites of Bachem, he has gained broad experience in development, scale up and manufacturing of peptides, both LPPS and SPPS. Dr. Seufert studied chemistry at the universities of Giessen and Leipzig and received his PhD from the University of Basel for his work on cyclization reactions of modified amino acids and peptides.

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