Spray Dried Dispersion Process Development

Drug Discovery and Development, Life Sciences, Pharma Manufacturing and Supply Chain, Pharmaceutical,
  • Thursday, March 10, 2016

Amorphous dispersions prepared by spray drying are a growing approach to improving the solubility and dissolution rate of many poorly soluble compounds. Bench-scale spray-drying units, like the Buchi Mini Spray Dyer B-290, are utilized for feasibility studies and in some cases being used as GMP production units for high-value low-volume drugs. As the product moves toward larger batch requirements, scale up to larger spray dryers is required. This presentation will focus on spray drying process development and will cover spray-drying equipment and scale-up of from the bench to pilot scale.

Come and compare your notes for scale with us. Topics will include:

  • Fundamentals of the spray drying process
  • Critical quality attributes & keys to successful spray drying
  • Closed vs open loop spray drying systems
  • Attributes and benefits of different nozzles
  • Process improvements during scale up
  • Typical processing equipment for spray dried intermediate


Jon Scrafford, Manager, Process Engineering, Pharmatek

Jon Scrafford, Manager, Process Engineering, Pharmatek

Jon Scrafford is the Manager of Process Engineering at Pharmatek. Jon has more than seven years of experience in the pharmaceutical industry, ranging from preclinical to commercial scale GMP manufacturing. At Pharmatek, he specializes in solid-oral formulation and process troubleshooting, scale-up and optimization, including cytotoxic compounds, granulation techniques and spray drying. Prior to joining Pharmatek, Jon worked as a Process Engineer at Genzyme in Boston in commercial-scale cell culture/protein purification manufacturing. He received Bachelor of Science in Chemical Engineering with a minor in Business, from Northeastern University in Boston. In his free time, Jon is a world traveler, an ardent sports fan, and an avid reader.

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Who Should Attend?

  • CEO & Presidents
  • Director / VP Drug Development, CMC, Manufacturing, Analytical Development, Formulations or Formulation Development
  • Director / VP Quality Assurance and Regulatory
  • Technical Section Managers
  • Principal Analytical Chemists
  • Team Leaders
  • Formulation Development Scientists
  • Consultants for Drug Development, CMC, QA

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Pharmatek is a contract development and manufacturing company for oral, injectable and topical products. Founded in 1999, our services focus on the rapid advancement of small molecule and peptide drug candidates from the bench to the clinic and include formulation and analytical development, cGMP manufacturing, and clinical packaging, labeling and worldwide distribution. Pharmatek’s experience includes first-in-man strategies, solutions for poorly soluble compounds, controlled release formulations and separate facilities for the handling of cytotoxic and potent compounds. Our drug delivery technologies include amorphous dispersions, particle size reduction, lipid delivery, complexation, lyophilization, suspensions and emulsions.

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