Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a highly motivated and energetic individual with a relevant scientific background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.

As a key member of Clinical Pharmacology group, you will:

• Responsible for clinical pipeline delivery through major milestones including IND/CTA, EOP2, and marketing applications NDA/sNDA.
• Lead the design and execution of an integrated clinical pharmacology and modeling and simulation strategy to guide the clinical development plan.
• Apply state-of-the-art quantitative pharmacology analyses, including PBPK, translational PK/PD, population PK, exposure-response analyses, and system pharmacology, to guide dose/schedule selection and recommended phase 2 dose and schedule (RP2Ds) selection.
• Author and provide technical input for regulatory documents and submissions related to all aspects of clinical pharmacology (including protocol, IB, briefing package, etc) and responses to regulatory questions.
• Engage and work with consultants and/or CROs on clinical pharmacology activities to complement in-house knowledge/expertise and capacities.
• Represent the clinical pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.

Required Experience, Skills, and Education:

• A Ph.D. or Pharm.D. with 3 to 5 years of relevant post-doc and/or industry experience in Clinical and Quantitative pharmacology.
• An MS with 5+ years of relevant industry experience in Clinical and/or Quantitative pharmacology.
• Experience hands-on modeling, and simulation skills using NONMEM, R, and/or other modeling and simulation software. Experience with population PK, Exposure-Response, and advanced mechanistic PK/PD models.
• Excellent verbal and written communication skills.
• A critical thinker and passionate team player with high energy who thrives in a dynamic and fast-paced environment.

Preferred Skills:

• Hand-on experience with PBPK models using SimCYP and PK-sim.
• Prior experience with small molecules in oncology drug development.
• Well-informed in current and emerging scientific standards of regulatory requirements and expectations.

The base salary range for this full-time position is $144,000 to $180,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.