Poseida Therapeutics is looking for an experienced and collaborative scientist to join our Translational Medicine team. This position provides a great opportunity for a highly motivated and creative individual to play a central role in our nimble and innovative clinical development program. We seek a well-trained and inspired immunologist to lead multifaceted studies that reveal how our CAR-T cell products enhance patient lives.

Position Summary

As a member of the Translational Medicine team, you'll contribute to characterizing our CAR-T cell products' clinical performance. This role involves integrating data, collaborating with various departments, and developing strategies to enhance our CAR-T therapies' effectiveness. By leading projects from inception to full-scale clinical testing and providing mechanistic insights, you'll help shape future clinical strategies and improve patient outcomes. This position is research-focused and includes laboratory and vendor management responsibilities.

Responsibilities 

These may include but are not limited to:

• Lead the characterization of CAR-T cell products' clinical performance by integrating multiple data streams from disparate databases (e.g. clinical, biomarker, -omics datasets, etc.)
• Collaborate with Clinical Biomarkers, Manufacturing Process Development, Pre-Clinical, and Statistical and Data Sciences to identify and evaluate trends in clinical data
• Develop a systems-biology perspective of individual subjects and identifying multivariable networks to model clinical performance across subjects
• Identify, develop, and launch novel and emergent methods, assays, and analytical strategies independently and as the interface between pre-clinical and clinical research teams
• Drive projects from inception through to full-scale clinical testing: complete proof of concept work independently, conduct medium-scale pilot studies with internal research support, assist in the launch of large-scale assays with Clinical Biomarkers and/or help Medical and Regulatory teams in writing and revising clinical trial documents

Requirements, Knowledge, Skills, and Abilities

• PhD in immunology, cellular biology, oncology, systems biology, or related field, and 5 plus years of experience in translational research and/or in vivo biology (an equivalent combination of education and experience may be considered)
• A highly proficient experimentalist with demonstrated success in independent and collaborative research projects
• Expertise in immunology and immune/oncology literature and state of the fields is required
• Prior experience in transplant immunology and/or immunogenetics is a plus.
• Strong working knowledge in diverse methodologies and fields of biology is desired.
• Proficiency in standard immunoassay methodologies (high-parameter flow/spectral flow cytometry, ELISA, Luminex, MSD), human T cell culture, and molecular biology techniques (qPCR, ddPCR, NanoString, NGS, scRNA-Seq, CITE-Seq).
• Experience in planning, executing, and analyzing single cell sequencing projects is desired.
• Proficiency in Microsoft Office and enterprise software (Word, Excel, PowerPoint, Teams, SharePoint, etc.) and high-performance computing systems (e.g. JMP, Prism, FlowJo, FACSDiva OMIQ etc.) is required; experience in programming languages (e.g. R and/or Python, Java) is desired.
• Ideal candidates are self-motivated and ambitious with a strong work ethic and excellent communication skills.
• Travel may be required up to 10% of the time, must be physically able to lift 35 pounds.

Sr. Scientist, Translational Medicine Pay Rate: $126,000 to $157,000 annually

The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.

Who We Are and What We Do

Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients’ lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.