Importance of Spatial Distribution Insight from Clinical Biopsies

Life Sciences, Biomarkers,
  • Tuesday, July 19, 2022

Current immuno-oncology research is revealing diagnostic, prognostic and predictive cell states and identities with implications for drug and diagnostic development as well as diagnostic testing. However, it is challenged in that only a minority of patients respond.

This is especially prevalent using therapies that rely on immune activation such as checkpoint inhibitors, due to the complex and heterogeneous immune escape mechanisms which can develop in each patient. Therefore, the development of robust biomarkers, enabling rational patient selection and the design of precise combination therapies, is key for the continued success and improvement afforded by this valuable treatment. The need for spatial distribution in clinical biopsies is now more than ever.

Today, spatial biology is finally giving researchers much needed contextual information resolving cells and biomarkers. It provides a comprehensive study of cellular composition, cellular functions and cell-cell interactions within the tumor microenvironment (TME).

Join this webinar to learn how spatial biology can provide insights into the spatial distribution and cellular interactions in clinical tumor biopsies.

Speaker

http://Jay%20Lee,%20Ultivue

Jay Lee, MD/PhD, Director of R&D and Innovation, Ultivue

Jay Lee is a highly published MD/PhD with over 25 years’ scientific experience, most recently leading a successful research group at Cold Spring Harbor Laboratories (CSHL) that focused on innovative imaging and molecular sequencing methods for tracking genes, molecules and cells to understand how cancer cells arise and evolve. Prior to his tenure at CSHL, Jay was a Scientist at the Wyss Institute for Biologically Inspired Engineering in Boston and spent many years as a Postdoctoral Research Fellow under Professor George Church at Harvard Medical School, Boston. His highly cited work on the generation and in situ sequencing of whole transcriptome libraries has been seminal to how we consider highly multiplexed and spatially resolved techniques today.

Message Presenter

Who Should Attend?

This webinar will be of particular interest to Scientists, PhDs and Post-docs in immuno-oncology research and computational pathology, Translational Scientists and Bioassay Experts.

What You Will Learn

Attendees will gain insights into:

  • A review of current spatial techniques
  • A demonstration of a streamlined spatial workflow supporting whole slide imaging coupled to advanced quantitative artificial intelligence (AI)-driven image analysis
  • An application of an 8-plex mIF and H&E fusion on a single tissue slide for a comprehensive tissue immunophenotyping analysis of tumors

Xtalks Partner

Ultivue

Ultivue, Inc. provides researchers and scientists with multiplex biomarker assays for tissue phenotyping and digital pathology. Its proprietary InSituPlex® technology enables advanced exploration and interrogation of tissue samples for precision medicine research. These highly customizable solutions and scientific consultative approach strengthen and accelerate biomarker discovery and drug development programs. For more information, visit ultivue.com

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