Pliant is seeking a talented and highly motivated individual with a strong background in analytical chemistry to join our chemistry team in the pursuit of novel small molecules to treat fibrotic disease. The R&D Manager, Analytical Chemistry is responsible for independently performing routine and non-routine analytical testing of novel chemical entities in our state-of-the-art analytical lab. The successful candidate will have familiarity with multiple analytical techniques critical for the purification and identification of novel chemical entities and have strong problem-solving abilities.

Responsibilities

• Demonstrated experience with chromatographic purification and compound characterization
• Manage, operate, and maintain analytical laboratory equipment including UPLC-MS, SFC, HPLC, and mass-directed purification systems
• Implement and contribute to the development of analytical and purification methods as required for high throughput chemistry libraries
• Conduct in-vitro ADME assays for permeability
• Provide regular progress updates to the chemistry team
• Maintain an accurate and detailed electronic lab notebook
• Manage and develop junior lab personnel to high levels of productivity

Qualifications

To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, abilities and prior experience required.

• BS in chemistry or related field with 10+ years of relevant experience in analytical chemistry or MS with 8+ years of relevant experience in analytical chemistry.
• A minimum of 2 years managing a direct report is required.
• Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
• Excellent troubleshooting skills and perceptive mechanical problem-solving ability.
• Experience with small molecule purification equipment and procedures using UV and/or MS-directed prep-HPLC. NMR experience is a plus.
• Enthusiastic and self-motivated with effective time management skills.
• Ability to work independently and perform well in a team environment.
• Ability to thrive in a culture of respect, accountability, transparency, and collaboration.

Pliant requires all new hires to be fully vaccinated prior to the first date of employment (subject to any legally required exemptions).