MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.  Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

The VP, Translational Medicine, is responsible for leading a research team focused on the pre-clinical, near-clinical, and clinical translation of novel biotherapeutic molecules in the immune-oncology space. She/he will be a key member of a discovery-focused leadership team responsible for designing and implementing a multi-year strategy for the development of the company’s immuno-oncology pipeline from the preclinical stage through early and late clinical development stages.

The general focus will be on assessing clinical developability, indication selection and/or prioritization, and defining mechanism-of-action-related biomarker strategies, with an emphasis on identifying effective target dose ranges. More specifically, she/he will be responsible for the design and implementation of translational medicine plans based on:

1. An assessment of our pre-clinical and clinical stage assets, inclusive of an analysis of the suitability of our targets, molecular entities and formats to meeting our clinical needs,
2. A definition of biomarker strategies suitable for indication selection, monitoring of clinical activity, and dose selection studies, among others,
3. A critical evaluation of internal and external technologies and opportunities suitable to meet our goal,
4. A definition of deliverables and resource needs,
5. Building an internal programmatic consensus across stakeholders,
6. Building external relationship with research organization and academia to implement our translational strategy,
7. Seeking endorsement at the company leadership level, and
8. Managing its implementation in a timely fashion and according to timelines.

The candidate will also provide expert support to both pre-clinical and clinical scientists in the discovery, characterization, and development of our therapeutic immune-oncology products. She/he will participate in designing the Company’s public relation strategy and will represent the Company in public fora as well as to partners, collaborators, and in Business Development-related activities.

Responsibilities and Job Duties:

• Provide immuno-oncology translational medicine expertise in leading the design of a strategy to enable a robust pipeline, encompassing therapeutic molecules, biomarker development, and potential diagnostics as needed.
• Actively collaborate with the clinical group to provide insights and achieve consensus on indication selection, prioritization, and segmentation to maximize the opportunity for clinical success.
• Work closely with the Company’s senior leadership to align on portfolio priorities, identify resource needs for priority programs, and build and foster internal cross-sector collaboration with key stakeholders to advance novel drug-strategies.
• Lead, coach, develop, and guide a core team of direct and indirect reports focused on the delivery of the immuno-oncology portfolio strategy, ensuring that all team members contribute to the mission of the group, perform at their highest levels, delivers in a timely fashion, and that the appropriate stakeholders are involved.
• Champion external opportunities to accelerate/broaden the strategy by working in close partnership with Business Development and Clinical Research and other stakeholders.
• Work with external collaborators to ensure an integrated and strategic approach in the execution of partnered projects and provide scientific oversight and management of collaborations and contracts.
• Establish and maintain a relationship with key opinion leaders, academic institutions, clinical investigators, and/or scientific advisory boards as appropriate to execute strategy.
• Present the company’s research in external settings, including conferences, partners, collaborators and in Business Development-related activities.

Minimum Qualifications

Education & Other Credentials

• M.D. or Ph.D. in immunology, microbiology, molecular biology, or equivalent degree.

Required Experience

• Minimum of 15 years of academic and/or industry research experience, with at least 10 years spent in translational science / biomarker discovery.
• Minimum of 10 years in hands-on leadership position with 5 or more direct reports.
• Minimum of 5 year of industrial experience.
• In-depth knowledge of immunology, cell biology, and immune biomarkers, with experience in immuno-oncology.
• Experience in biotechnology and development of monoclonal antibody for therapeutic use.

Knowledge, Skills, and Abilities

• High integrity and a passion for drug development.
• Entrepreneurial mindset, with an ability to take calculated risks and deliver on challenging projects.
• Ability to work as a member of high-performing teams.
• Exceptionally strong leadership skills, with proven ability to lead a successful research group in basic or applied research in cellular immunology.
• Accomplished record of scientific publications and presentations on a global level.
• Outstanding communications skills, with strong verbal and written communications abilities, and an ability to identify and deliver correct messaging in front diverse audiences.
• Ability to wear multiple hats and pivot with changing priorities.
• Ability to ‘hit-the-ground running’, with no learning curve whatsoever.

Preferred Qualifications

Preferential consideration will be given to individuals with prior leadership experience in a management role in the biotech industry and /or those considered scientific thought leaders in the field of immune oncology research.

Supervisory Responsibilities

Yes

Additional Information

The annual rate of pay for this position ranges from $251,000 to $404,000. For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company’s discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company’s benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.

The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate’s experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company’s sole discretion, consistent with the law.