ATMP Manufacturing Processes: Using Computer Simulation to Improve Operational Efficiency

Computer simulation empowers life sciences companies involved in manufacturing of advanced therapy medicinal products (ATMPs) to understand their systems and processes, compare scenarios and alternatives, and justify the cost of manufacturing and manufacturing-related processes.

More importantly, it can spur significant reductions in operating costs, capital costs, implementation time, and risk.

But what does computer simulation mean exactly in the context of ATMP manufacturing?

Simulation tools are computerized algorithms that use statistical modeling to predict the requirements for new manufacturing facilities. These tools estimate parameters such as equipment utilization; consumption of water, media, and buffer; and sampling frequency. The output of the simulation can be used to determine the size of ATMP manufacturing rooms, storage areas, and laboratories, as well as staffing and resource requirements, warehouse capacity, and the effects of variability.

This webinar will highlight the advantages of simulation and how the inputs used in the models can affect the results obtained. The quality of inputs is crucial. A poor input will result in poor output. But when the available data is used strategically, it can result in cost savings and operational efficiencies in ATMP manufacturing.

These benefits include:

• Uncovering relationships between manufacturing steps that may affect throughput or efficiency
• Predicting equipment utilization
• Calculating the consumption of single-use components and estimating the quantity of in-process drums and containers
• Encouraging the operations team to clearly define boundaries, such as staffing hours and product hold times

The featured speaker will highlight case studies from common ATMP manufacturing processes, such as CAR-T and viral vector, to demonstrate the principles discussed. These examples will highlight the value of using an analytic simulation tool, which is programmed using Microsoft Excel for these scenarios.

Register for this webinar to learn how simulation tools can be used to streamline ATMP manufacturing.

Speaker

Steve Hall, Chief Process Engineer, Genesis AEC

Stephen Hall has over 40 years of experience combining business understanding with technical expertise to deliver capital projects and services with exceptional value, speed, and compliance. Steve is recognized internationally as an expert on process engineering for upstream manufacturing facilities including small and large molecule APIs, critical utilities, CIP systems and material transfer. His book, Rules of Thumb for Chemical Engineers, 6th Edition, is a highly regarded handbook for process and project engineers. His engineering software is used globally for sizing pipelines and designing heat transfer systems.

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