Accelerating Neurodegenerative Clinical Drug Development with AI

Life Sciences, Clinical Trials, Drug Discovery & Development,
  • Wednesday, September 18, 2024

Rapid advancements in artificial intelligence (AI) are revolutionizing central nervous system (CNS) clinical trials in neurodegenerative diseases by improving patient recruitment, optimizing study protocols, analyzing data in greater depth and personalizing treatments. These advances not only enable more efficient and accurate clinical trials, but also speed up the development of new treatments and improve patient outcomes.

AI is revolutionizing the landscape of drug discovery and clinical drug development, particularly within central nervous system (CNS) research for neurodegenerative diseases. The emerging importance of AI in neurodegenerative diseases is underscored by the fact that CNS drug development, in general, has higher failure rates than non-CNS drugs, both preclinically and clinically, indicating that more research is required to ensure safety and efficacy in treatments to slow neurodegeneration.

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Development times for neurodegenerative disease drugs are significantly longer, particularly for those that are ultimately approved. Additionally, the post-development regulatory review process is often extended. Failure rates are mainly due to the complexity of the brain and nervous system and lack of understanding of the underlining mechanisms that lead to brain disorders and neurodegeneration. Consequently, neurodegenerative drug discovery and development programs have been subjected to significant cutbacks and eliminations over the last few decades, affecting the entire drug development pipeline, from discovery through to clinical trials and regulatory approval.

The integration of AI has enhanced the understanding of mechanisms, accelerated novel target identification and fueled advances in drug discovery for neurodegenerative diseases and other CNS disorders. It has helped in generating compounds with unique properties, such as improved specificity or bioavailability. Overall, AI holds immense promise for understanding, diagnosing and managing neurodegenerative diseases, ultimately improving patient outcomes.

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Register for this webinar today to gain insights on how AI is playing a crucial role in advancing CNS research related to neurodegenerative clinical drug development.

Speakers

Anne-Marie Nagy, PhD, Vice President, Head of Internal Medicine & Neuroscience, TFS HealthScience

Anne-Marie Nagy joined TFS in September 2021 to lead the company’s Internal Medicine and Neurosciences Business Units. Her strategic and operational experience from nearly 25 years at both mid-and large-sized pharmaceutical and clinical research organizations has benefited biotech clients throughout their clinical development journey.

She has extensive experience in neuroscience with broad indications such as those in psychiatry (schizophrenia, MDD, bipolar disorders and anxiety) and neurology, including rare and gene therapy (spasticity, cervical dystonia, rare and non-rare epilepsy, Alzheimer’s, Parkinson’s, multiple sclerosis, neuromuscular disorders, Friedreich ataxia and Rett syndrome).

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Anne-Marie specializes in Internal Medicine indications in women’s health and pulmonary inflammatory diseases (ARDS, asthma, cystic fibrosis, COPD and Covid-19). She possesses drug development and clinical operational expertise across large clinical programs in neurology, psychiatry, pain and cystic fibrosis across all phases in NA, EMEA, South Africa, ASIA PAC and LA, as well as in the peri-post approval drug market. Anne-Marie holds a PhD in Biomedical Sciences from the Faculty of Medicine of the Free University of Brussels, Belgium. She has received numerous academic honors and has several scientific publications in reproductive endocrinology and pulmonary inflammatory diseases.

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Sara Doan, BSc, DC, Executive Director, Program Strategy, Internal Medicine & Neuroscience, TFS HealthScience

Dr. Sara Doan is the Executive Director, Program Strategy and Delivery for Internal Medicine & Neuroscience. She brings a robust 27-year background in global clinical research to her role, with a particular emphasis on psychiatry over the past 12 years. Her expertise spans a broad range of disorders including Alzheimer’s, Parkinson’s, Narcissistic Personality Disorder, Borderline Personality Disorder, Major Depressive Disorder, Post Traumatic Stress Disorder, Bipolar Disorder, Migraine and Anxiety.

Dr. Doan is a Doctor of Chiropractic with a specialization in the central nervous system, having earned her degree from Parker University in Dallas, Texas. She is proficient in both English and Farsi. Dr. Doan demonstrates forward-thinking leadership with a proven track record of success in business operations, coupled with a commitment to excellence in customer management and a strong emphasis on delivering high-level customer service.

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She takes accountability for developing and executing strategic initiatives, driving development and overseeing operational planning across diverse functions within the organization. With nearly three decades of invaluable experience in the biotech and clinical research organization sectors, she contributes a wealth of knowledge and insights to every project and initiative.

Recognized for her exceptional ability to cultivate and lead high-performing teams, Dr. Doan emphasizes cohesion, morale, open dialogue and a culture of accountability that fosters innovation and collaboration. She possesses extensive expertise in clinical and project management throughout all stages of clinical trials, with a notable record of successfully leading and managing study teams across fully scoped multicenter studies spanning regions, including North and Latin America, Europe, Asia and Australia.

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Who Should Attend?

This webinar will appeal to senior professionals from pharma and biotech companies involved in:

  • Clinical trials
  • Clinical operations
  • Data management
  • Drug development
  • Preclinical trials
  • Project management
  • Regulatory affairs

What You Will Learn

In this webinar, attendees will learn about:

  • The role of AI in dissecting disease pathogenesis
  • How AI can improve success rates in neurodegenerative drug discovery
  • Methods for accelerating CNS clinical trials with AI, enhancing patient journeys and drug accessibility

Xtalks Partner

TFS HealthScience

TFS HealthScience is a full-service, global Contract Research Organization (CRO) that supports biotechnology and pharmaceutical companies throughout their entire clinical development journey. In partnership with customers, we build solution-driven teams working towards a healthier future. Bringing together nearly 800+ professionals, TFS delivers tailored clinical research services in more than 40 countries with flexible clinical development and strategic resourcing solutions across key therapeutic areas, including Dermatology, Immunology & Inflammatory DiseasesInternal MedicineNeuroscienceOncology & Hematology, and Ophthalmology.

Detailed information about TFS and its business offerings can be obtained through www.tfscro.com.

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