While synthetic biology has considerably advanced in the past decade, cost continues to be a major factor in commercial viability. Saccharomyces cerevisiae is a commonly used microbial host in synthetic biology. These cultures can be grown to very high densities with high expression levels of target molecules, making S. cerevisiae a preferred candidate for cost-effective natural product synthesis.
In this webinar, the expert speakers demonstrate the seamless scale-up of a high-yield fermentation process from 250 mL to 5 L, enabled by extensive vessel characterization using cloud-connected bioreactors. The speakers will share insights into how utilizing S. cerevisiae provided an efficient and cost-effective scale-up method.
They will also present case studies that illustrate the steps taken to reduce costs and mitigate risks during the scale-up process. The attendees will also gain a comprehensive understanding of how cloud-connected bioreactors can dramatically accelerate the scale-up process in biomanufacturing. The speakers will then delve into practical troubleshooting methods, designed to address and overcome common challenges encountered during scale-up.
Moreover, the session will explore effective strategies for reducing costs and de-risking the scale-up process, equipping attendees with tools and knowledge needed to optimize production efficiency and ensure successful outcomes in their biomanufacturing projects.
Register for this webinar to discover how cloud-connected bioreactors are revolutionizing the scale-up process for biomanufacturing.
Speakers
Andrew Horwitz, PhD, Vice President Research and Development, Inscripta
Andrew Horwitz is an R&D leader drawing on 15 years’ experience in industrial biotech / synthetic biology with a view from concept to commercialization of multiple products. His work focuses on the production of natural products in microbial hosts such as baker’s yeast to create scalable and sustainable supply chains.
At Amyris, Andrew led a team that developed CRISPR strain engineering tools and applied them to accelerate the timelines for products ranging from fuels to pharmaceuticals. At Demetrix and Sestina, Andrew was responsible for establishing R&D labs and technical teams to achieve early technical milestones. At Inscripta, Andrew leads the Product Development team, with responsibilities in strain and process development from feasibility through scaleup.
Message Presenter
Kris Tyner, Senior Director, Bioprocess Sciences, Culture Biosciences
Kris Tyner has extensive experience in microbial fermentation and cell culture, specializing in upstream bioprocess development. At Culture Biosciences, she leads internal R&D initiatives while also playing a key role in onboarding new clients, facilitating technical transfers and ensuring seamless scale-down into Culture’s bioreactors.
Before joining Culture, Kris worked at Zymergen, where she managed the tech transfer and scale-down of fermentation processes, including the use of 96-well plates for high-throughput screening. Her work provided technical leadership across a range of fermentation projects. Prior to Zymergen, Kris was a Senior Scientist at OPX Biotechnologies, focusing on physiology and bioprocess research, where she developed expertise in working with a diverse array of organisms such as bacteria, yeast, filamentous fungi, and mammalian cells. Her research centered on the critical connection between cellular physiology and bioprocess performance.
Kris holds a BS in Genetics and Microbiology from Monash University in Melbourne, Australia. She completed her graduate studies in molecular, developmental and cellular biology, with a focus on muscle stem cell signaling, at the University of Colorado, Boulder. She then completed a postdoctoral fellowship at National Jewish Health, where she conducted research on macrophage cell signaling.
Message PresenterWho Should Attend?
This webinar will appeal to:
- Small-Mid-Large Biotech/Pharma
- Emerging biotechs and startups/Agricultural biotechnology firms
- Food Technology and fermentation-based food companies
- Biofuel and renewable chemical companies
- Research institutions and academia
- Bioprocess Engineers
- Head of Process Development/Innovation
- Upstream Process Development Scientists
- Formulation Scientists
- Product Development
- Consultants/R&D/Scientists/Formulators
What You Will Learn
Attendees will learn about:
- How cloud-connected bioreactors can accelerate scale-up
- Troubleshooting methods to overcome scale-up challenges
- Strategies for reducing costs and de-risking scale-up
Xtalks Partner
Culture Biosciences
At Culture Biosciences, we partner with Biopharma/Biotech clients who develop protein and gene therapies accelerating cell culture process development (PD). Culture utilizes innovative cloud-connected bioreactors and data science capabilities driving the digital transformation of biomanufacturing. Culture’s real-time data analysis and data-driven modeling capabilities, enable clients to accelerate their biomanufacturing screening and optimization work. Culture has worked with over 70 clients collaborating with PD labs on design of experiments (DoE), debottlenecking PD and de-risking outcomes.
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