Accelerating RNA Therapeutics Discovery: From HELM-Based Design to Data-Driven Candidate Selection

The rise of RNA-based therapeutics — including antisense oligonucleotides (ASOs), siRNA and mRNA — has transformed modern drug discovery. Yet, these modalities come with complex workflows, cross-functional coordination and high data volumes that challenge many organizations.

In this webinar, the featured speakers will walk through a complete, end-to-end RNA therapeutics R&D workflow, demonstrating how the Design-Make-Test-Decide (DMTD) cycle can be streamlined within an integrated digital environment.

Attendees will see how unifying design, experimentation and analysis in a single system can help research teams move from concept to lead candidate more efficiently, collaboratively and with greater confidence.

Starting with ASO design, the webinar will demonstrate how using standardized notation formats, such as hierarchical editing language for macromolecules (HELM), can simplify oligo construction and ensure consistent data capture for downstream workflows.

From there, the speakers will explore how digital tools can support the registration and documentation of synthesis, analytical characterization and assay protocols within a connected environment.

Finally, they will show how integrated data analysis and visualization capabilities enable robust multiparameter evaluation of candidates based on factors such as biological efficacy, stability and off-target risk.

By unifying tools and eliminating data silos, an integrated digital environment can accelerate decision-making and allow R&D teams to focus more on innovation and less on managing fragmented data.

Register for this webinar to learn how integrated, data-driven workflows can streamline RNA therapeutics discovery and improve the speed and quality of candidate selection.

Speakers

Lindsey Rickershauser, PhD, Product Manager, ChemDraw, Revvity Signals

Lindsey Rickershauser is the Product Manager for ChemDraw at Revvity Signals. Graduating with her PhD in Organic Chemistry from Johns Hopkins University, she went on to spend several years at the bench where she specialized in the synthesis of stable label isotope molecules in the clinical, diagnostic and forensic testing industries. She turned her focus to cheminformatics and software development, where she helped to develop, commercialize and launch a leading retrosynthesis software prior to taking on her current role. She is passionate about delivering value and innovation to chemists around the globe.

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Larry Mulcahy, PhD, Product Manager, Biologics, Revvity Signals

Larry Mulcahy is a Product Manager for Biologics at Revvity Signals. His scientific training and research background include biochemistry, molecular biology, endocrinology and academic drug discovery. He has spent the last several years in software as a scientific solution consultant across industries with a heavy focus on biopharma R&D.

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Zev Wisotsky, PhD, Senior Principal Marketing Manager, Biologics Solutions, Revvity Signals

Zev Wisotsky is a Senior Principal Marketing Manager for Biologics Solutions at Revvity Signals. His scientific training and research background include neuroscience, biochemistry, molecular biology and drug discovery. He has spent almost 10 years in software in go-to-market teams across industries with a heavy focus on biopharma/biotech R&D.

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