Principles for Sustainable Flash Chromatography: Reducing, Reusing and Optimizing for a Greener Workflow

Life Sciences, Pharma Manufacturing & Supply Chain,
  • Thursday, March 27, 2025 | 1pm EDT (10am PDT)
  • 60 min

Discover in this webinar how technology can be leveraged to advance green initiatives, specifically when it comes to purification, the most wasteful component of the small molecule synthesis workflow.

Greener practices in chemistry labs like reducing waste generation and increasing use of safer solvents are major focus for organizations and research groups that synthesize and purify new molecules or drug candidates. Automated flash purification offers a fast, flexible and cost-effective method for purifying synthetic products, allowing researchers to focus on more important tasks.

However, built-in purification gradients have encouraged researchers to minimize optimization of their chromatographic methods. It is well established that purification adds a significant amount of solvent usage due to unoptimized methods, requiring duplicated efforts when the first purification fails.

Additionally, several solvents that have been a common place in chromatography are now classified as harmful and hazardous, leading to use restrictions and the need to develop improved methodologies for benchtop chromatography while not sacrificing the speed of delivery of novel molecules.

During this webinar, the expert speakers will present strategies for flash purification as it is commonly performed but highlight imbedded, improved technology that allows for simple optimization of gradients that reduce solvent usage. They will also highlight alternative chromatographic strategies that reduce or eliminate restricted solvents for greener purifications overall.

Register for this webinar to explore how automation and optimization in flash purification can considerably reduce waste and hazardous solvent use in small molecule synthesis.

Speaker

Austin Schlirf, Biotage®

Austin Schlirf, Application Scientist, Biotage®

Austin Schlirf has a background in Biomedical Engineering where he researched a variety of biomaterial applications from synthetic bioinspired hydrogels to mucin glycopeptide mimetics.

Austin serves as an Application Scientist at Biotage® where his role supports the North American system install bases for peptide and small molecule research. This includes the Biotage workflow of products, including synthesis, purification and dry down of samples on the R&D scale up to clinical testing.

Message Presenter

Who Should Attend?

This webinar will appeal to:

  • Graduate students
  • Post-doctoral fellows
  • Research Associates/Research Scientists
  • Professors/Lab Managers
  • Those interested in automation strategies

What You Will Learn

Attendees will learn about:

  • Strategies to reduce solvent consumption during flash purification
  • Alternative solvents and modifiers for greener purifications, including eliminating DCM as a mobile phase solvent
  • Combining technology and flash theory to perform fewer separations

Xtalks Partner

Biotage®

Biotage® is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in drug discovery and development and diagnostics, analytical testing and water and environmental testing.

Biotage® is contributing to sustainable science with the goal to make the world healthier, greener and cleaner – HumanKind Unlimited.

Our customers span a broad range of market segments, including pharmaceutical, biotech, diagnostic, contract research and contract manufacturers as well as clinical, forensic and academic laboratories, in addition to organizations focused on food safety, clean water and environmental sustainability.

We offer workflow solutions and products to customers in peptide synthesis, drug discovery and development, and analytical testing. Our range of tools increases speed and efficiency of all steps in the peptide synthesis workflow while improving the quality of peptides synthesized.

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