Healthcare Layoffs 2025: A Roundup

Healthcare organizations have long used workforce adjustments to respond to changing market dynamics, regulatory pressures and the need to refocus on core patient care. In this blog, we detail the healthcare layoffs in 2025, examining the underlying factors and potential ramifications for the industry.

In 2024, major players like CVS Health and Bio‑Rad Laboratories made headlines by trimming their staff. CVS Health reportedly cut over 1,000 jobs, while Bio‑Rad slashed more than 350 positions in response to financial pressures, which included a net loss of $1.84 billion.

These sweeping changes underscored the urgency for healthcare systems to realign their resources and streamline operations. Rising operating expenses — spurred by supply chain disruptions, increased labor costs and regulatory pressures — have forced many healthcare organizations to cut staff in order to remain financially sustainable.

As we move into 2025, new announcements signal that organizations seek to create leaner, more agile operations capable of meeting the challenges of today’s healthcare environment.

HealthCare Layoffs in 2025: A Closer Look

Cleveland Clinic (OH)

Cleveland Clinic, a globally renowned academic medical center and leader in clinical innovation, is eliminating 114 jobs, according to a Fox8 report.

Despite these healthcare layoffs, the organization continues to hire in critical areas. Cleveland Clinica remains committed to expanding its impact by improving primary care access in Mahoning Valley and advancing education in quantum computing through a strategic partnership with Miami University.

Main Line Health (PA)

Main Line Health offers integrated healthcare services that focus on delivering high-quality, patient-centered care across its network.

According to MSN, Main Line Health is laying off nearly 200 nonclinical staff — approximately 15% of its workforce — to streamline administrative functions and reduce costs. This measure aims to enhance operational efficiency while maintaining the quality of patient care in its core clinical areas.

Advocate Health/Walgreens Partnership (IL)

NBC Chicago reported that Advocate Health, in collaboration with Walgreens, is set to close 47 outpatient clinics in Illinois as both organizations work together to optimize operations and reduce costs.

As one of the nation’s largest health systems, Advocate Health is integrating hospital and retail pharmacy services to create a more cohesive patient service model.

Earlier in 2024, the company made headlines by canceling a substantial debt at a North Carolina hospital, reinforcing its commitment to financial stability and reinvestment in patient care.

Mass General Brigham (MA)

Boston 25 News reported that Mass General Brigham, one of Massachusetts’ largest employers, plans to lay off hundreds of employees over the next two months as part of a broader restructuring to address a $250 million budget deficit.

With layoffs affecting management and administrative roles across 12 hospitals, this initiative aims to reduce $200 million in salary and benefit expenses while ensuring that frontline patient care remains robust.

Endeavor Health (IL)

According to a recent NCH report on Patch, Endeavor Health will end inpatient psychiatric services at Northwest Community Hospital in Arlington Heights on April 11, eliminating 100 jobs. The move comes amid significant cost pressures and a shift toward outpatient, telehealth care — while affected employees may be considered for other roles within the system.

Jefferson Health (PA)

Jefferson Health — a comprehensive healthcare system providing integrated patient care, research and education — is laying off 171 back-office employees, according to The Philadelphia Inquirer. The decision is part of broader cost-cutting measures aimed at streamlining administrative functions as the organization adapts to evolving financial pressures.

The ongoing workforce adjustments in 2025 are a clear sign that healthcare organizations are committed to reshaping their operations amid economic and regulatory challenges.

As these changes take effect, stakeholders across the healthcare ecosystem will need to stay informed and adapt to the evolving environment — a shift that began in 2024 and continues into 2025.