MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.  Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

As head of Protein Sciences within the Research department, you will lead a group of scientists focused on the purification and characterization of proteins (antibodies, bi/multispecifics, ADCs) by state-of-the-art chromatography and analytical technologies. Your group will collaborate with other Research groups to deliver and test high quality proteins in cell-based assays, mouse tumor models and in NHP studies. Interacting with downstream groups, you will facilitate the transition of lead candidates from Research to Development. As a scientific expert, you will be responsible for identifying opportunities and driving innovation in protein purification, characterization and developability assessment. As a people manager, you will invest in the growth and development of your staff to maintain a culture of collaboration and accountability.

Responsibilities and Job Duties

• Lead a team of scientists focused on protein purification and conjugation, biophysical characterization and developability assessment of protein therapeutics.
• Lead and mentor group members to work efficiently, collaboratively, and innovatively.
• Manage priorities, resources, and investments in alignment with the Research strategy
• Represent the Protein Sciences group in Research Project Teams
• Collaborate with Biophysical Development and CMC groups to facilitate efficient advancement of therapeutic candidates from Research to Development.
• Assess new technologies and methods to advance existing capabilities and improve platforms and workflows.

Qualifications

Associate Director, Protein Sciences

Education & Experience

• Ph.D. in Biochemistry or a related field with 8+ years of industry experience
• Experience in advancing protein therapeutics from discovery to development
• Strong understanding of antibody structure to aid in design and testing of product candidates
• Experience in leading a team of protein scientists and communicating timelines and priorities.
• Self-motivated with an ability to handle multiple projects, meet deadlines and make decisions
• Excellent communication and collaboration abilities

Director, Protein Sciences

Education & Experience

• Ph.D. in Biochemistry or a related field with 10+ years of industry experience
• Experience in advancing protein therapeutics from discovery to development
• Strong understanding of antibody structure to aid in design and testing of product candidates
• Experience in leading a team of protein scientists and communicating timelines and priorities.
• Self-motivated with an ability to handle multiple projects, meet deadlines and make decisions
• Excellent communication and collaboration abilities

Knowledge, Skills and Abilities

• Deep expertise in protein expression utilizing multiple platforms and scales, and chromatographic separation techniques for protein purification.
• Strong technical knowledge of analytical characterization techniques, including HPLC analytical methods, CE-SDS, mass spectrometry, DLS, thermal stability, SPR, and BLI techniques.
• Expertise in conjugation techniques, linker chemistry and bioconjugate characterization methods.

Preferred Qualifications

• Familiarity with protein structure modeling
• Experience with electronic lab notebooks and LIMS
• Experience in lab automation, including automated analytical data acquisition, and analysis workflows

Supervisory Responsibilities

Yes – several Ph.D. and non-Ph.D. scientists

Additional Information

The annual rate of pay for this position ranges from $159,000 - $242,500 (Associate Director, Protein Sciences) and $184,500 –$281,300 (Director, Protein Sciences). For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company’s discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company’s benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.