Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Playing a leadership role within Pharmaceutical Development and Manufacturing (PDM) organization, the position will be responsible for leading PDM Operation and Portfolio Management function enabling cross-functional business operation needs including but not limited to strategic sourcing and supplier management, portfolio management, and operation excellence.  The individual will also play a critical role in, and participate in, the overall CMC strategy planning and execution.

• Lead global sourcing strategy development and execution to ensure appropriate and robust supply chain to support RVMD pipeline development and commercialization.
• Lead the efforts to assess/identify potential suppliers with adequate risks and benefits assessment.
• Provide business operational oversight for the external R&D and manufacturing activities.
• Lead business review meetings with collective feedback across PDM functions on the overall performance of the CDMOs and CTLs to ensure operational excellence.
• Establish scalable and robust PDM Portfolio Management systems, structures, and cultures while driving operational advancement and excellence.

• Collaborate with drug substance (DS), analytical development & QC (ADQC), drug product (DP), supply chain (SC), CMC PM, CMC regulatory and quality (QA) to ensure overall CMC goals are met.
• Travel to CDMOs for vendor assessment and qualification, as well as supplier oversight as needed.

Required Skills, Experience, and Education:

• Bachelor's in science.
• 18 + years of experience in the pharmaceutical/biotech industry with a sound track record of manufacturing operation, strategic sourcing and supplier management, operational excellence, and organizational leadership, with end-to-end development and manufacturing experience of small molecules.

• Proven track record of strategic leadership and management with at least 8 years in the leadership role.
• Demonstrated strong cross-functional team leadership and people management

• Good understanding and working experience in drug development and manufacturing with respect to GMP, quality systems, ICH guidelines, FDA, EMA, and associated regulatory requirements.

• Working experience with management and oversight of the development and manufacturing activities at CDMOs.
• Strong problem-solving skills with strategic and sound technically driven decision-making ability.
• Effective written and verbal communication skills and interpersonal skills.
• Innovative team player with high energy for our dynamic company environment.

Preferred Skills:

• BS, MS, or PhD in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field.