The Immuno-Oncology Principal Scientist will play a key role in supporting our multifaceted objectives to develop CAR-T in preclinical stage that will drive Poseida’s mission to cure patients of cancer. At this senior position, the Principal Scientist must work independently but also be a key thought leader dedicated to collaborative efforts and effective communication with key stakeholders. The Immuno-Oncology Principal Scientist will play a key role in exploiting our Cas-CLOVER and piggyBac platforms for genetic manipulation of T cells for the development of CAR-T. This scientist will also play a key role measuring the genotoxicity of CAR-T product.

Responsibilities 

These may include but are not limited to:

• Support the development of CAR-T cellular therapies at the preclinical stage.
• Support the programs at IND-enabling stage.
• Apply your background in molecular biology to evaluate genotoxicity (e.g. off-target, chromosomal rearrangement, etc) of CAR-T driven by RNA-guided nucleases (RGNs), site-specific nuclease, or transposases.
• Work in a highly collaborative, cross-functional team environment to evaluate/plan scientific strategies, communicate with CROs, design experiments, perform experiments, analyze results, and communicate findings in team meetings.
• Will train and assist other laboratory personnel, including new onboards, existing Scientists, Research Associates, and/or Research Technicians, while also troubleshooting with these members, as needed.
• Keep current on trends, new products and technologies in genotoxicity analysis.
• Manage Research Scientists or Research Associates

Requirements, Knowledge, Skills and Abilities

• PhD in molecular biology, cell biology with 8+ years of hands-on experience NGS data handling, from processing raw reads through to running or building pipelines for analysis.
• Expertise and proficiency with evaluating the fidelity of gene editing technology
• Hands on experience with NGS datasets (e.g. GUIDE-seq, rhAmp-seq, UdiTaS, AMP-seq, Long-Read Sequencing) are preferred.
• Expertise and proficiency with standard molecular biology assays (ddPCR, qPCR, RT-PCR).
• Expert working knowledge in either Python or R.
• Experience working in a Linux HPC environment and cloud-computing platforms (e.g. AWS).
• Critical thinking, drawing both from an extensive knowledge of current and historical scientific literature while also integrating knowledge from professional experience.
• Experience working with publicly available biological datasets (NCBI, gnomAD, SRA, GTEx)
• Must possess excellent oral and written communication skills.

Principal Scientist, Genotoxicity Salary Range: $144,000 to $170,000 annually

The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.