MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.  Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

This position is part of the Protein Science group within the Research department. The Scientist I/II will be responsible for the analysis of biomolecular interactions using Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) to analyze biomolecular interactions, primarily focusing on antibody-antigen binding kinetics in support of the biologics research pipeline. Additional roles include the purification of recombinant proteins and their characterization by HPLC and capillary electrophoresis.

Responsibilities and Job Duties

• Design, execute, and analyze SPR and BLI experiments to determine antibody affinities, kinetics, and epitopes.
• Maintain SPR and BLI instruments
• Purify proteins and perform routine analytical characterization
• Confirm protein identity by Liquid Chromatography-Mass Spectrometry (LC-MS)
• Conduct protein stability tests for lead molecule selection
• Maintain timely and accurate records

Minimum Qualifications

Scientist I

Education & Other Credentials

• Bachelor’s (BS/BA) in Biochemistry or a related scientific field of study with 3+ years of bench-related experience within industry and/or academia.

OR

• A Master’s degree in Biochemistry or a related scientific field of study with 0 years of bench-related experience within industry and/or academia.

Scientist II

Education & Other Credentials

• Bachelor’s (BS/BA) in Biochemistry or a related scientific field of study with 5+ years of strong bench-related experience within industry and/or academia.

OR

• A Master’s degree in Biochemistry or a related scientific field of study with 2+ years of strong bench-related experience within industry and/or academia.

Knowledge, Skills and Abilities

• Understanding of biophysical principles governing protein-protein interactions and binding kinetics
• Hands-on experience with SPR and BLI instruments
• Ability to handle multiple tasks and willing to collaborate with other teams
• Excellent written and verbal communications skills
• Maintain timely and accurate records 

Supervisory Responsibilities: 

No.

Preferred Knowledge and Skills

• Knowledge and experience about protein purification
• Hand-on experience with AKTA chromatography system preferred
• Hand-on experience with HPLC or LC-MS preferred

Additional Information

The annual rate of pay for this position ranges from $84,400 - $128,800 (Scientist I) and $94,300 - $143,800 (Scientist II). For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company’s discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company’s benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.