Amorphous Solid Dispersion — An Ideal Formulation Approach to Improve Developability of Poorly Soluble Molecules

Life Sciences, Drug Discovery & Development,
  • Wednesday, January 24, 2024

Discover an informative webinar uncovering the transformative impact of amorphous solid dispersion on drug solubility. Aqueous solubility results in low bioavailability and developability issues. Various approaches such as salt formation, solubilization using a co-solvent, complexation with cyclodextrin and particle size reduction have limitations for their wide applicability for all molecules.

Amorphous solid dispersion is one of the most promising approaches that not only helps overcome the limitations of these other approaches but also helps enhance the bioavailability and enable compounds to toxicity studies. The solid dispersion approach has unique advantages in terms of its applicability for a wide range of molecules, safety of vehicles and scalability.


Solid dispersion refers to the dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at the molecular level. It is prepared by the melt (fusion) method or the solvent evaporation technique. The basic principle of this technique involves the conversion of crystalline drug substance to an amorphous form and stabilised in a hydrophilic polymer.

When the solid dispersion comes in contact with the aqueous medium, the inert carrier dissolves releasing the drug and the increased surface area produces a higher apparent solubility and dissolution rate, thereby increasing the bioavailability of the poorly soluble drug substance.

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In this webinar, Sreehari Babu, Sr. Vice President — Formulations Solutions at Aragen Life Sciences, will deep dive into how amorphous solid dispersion is an ideal approach for poorly soluble drug substances and demonstrate how Aragen can offer end-to-end solutions from screening to good manufacturing practice (GMP) supplies through technology overview and case studies.

Join this webinar to learn how amorphous solid dispersion revolutionizes drug solubility, addressing aqueous solubility challenges for enhanced bioavailability and pharmaceutical development.


Sreehari Babu Putchakayala, Aragen Life Sciences

Sreehari Babu Putchakayala, SVP & Head, Formulation Development Solutions, Aragen

Sreehari Babu Putchakayala has over 20 years of experience in pharmaceutical development, with 14 years in leadership roles covering early phase, drug discovery support, product development in drug discovery R&D, generics formulation development and clinical supplies management. Sreehari previously worked with Novartis Pharmaceuticals, Ranbaxy Research Laboratories and Dr. Reddy’s Laboratories.

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Who Should Attend?

This webinar will appeal to professionals in the following fields and with the following job titles:

  • Research/Principal/Lead/Associate Director/Director level Scientists working on formulation, pre-formulation, analytical development, pharmacokinetics, PK/PD studies, drug development, drug products
  • VP/SVP/EVP of Formulation, Chemistry, Biology, CSO
  • Manager/Team Lead level related to formulation

What You Will Learn

Attendees will gain insights into:

  • Understanding how amorphous solid dispersion differs from traditional methods, enhancing bioavailability across various drugs
  • Exploring how amorphous solid dispersion improves drug solubility upon dissolution, boosting dissolution rates
  • Amorphous solid dispersion applications for poorly soluble drugs, supported by case studies and comprehensive solutions from screening to GMP supplies

Xtalks Partner


Aragen Life Sciences is a leading R&D and manufacturing solutions provider for the life sciences industries worldwide. It offers end-to-end integrated or standalone solutions for small and large molecules. Established in 2001, the Company operates through a network of sites located globally with a team of 3700+ scientists and 450+ PhDs. Its expertise and experience have enabled over 400 customers to advance their research programs from discovery through commercialization. Aragen’s innovative mindset, infrastructure, flexible business models have enabled us to serve large pharma, biotech, agrochemical, animal health and performance chemical industries globally. Visit for more details.

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