From BMI to BCP: Body Composition Profiling with MRI for Metabolic Disease Management, Health Risks and Healthy Lifestyle Choice

Life Sciences, Clinical Trials, Healthcare,
  • Tuesday, June 21, 2022

In the search to understand metabolic disease, prevention and treatments, people are often broadly categorized using relatively crude tools. For example, obesity is commonly described using BMI (body mass index, weight in kg / height in m2 ), and individuals are placed in one of five categories ranging from underweight to obesity. However, the health risks related to obesity are more closely linked with body composition — which is the amount of muscle and fat in the body — than with anthropometric (human body) measurements, such as body weight, BMI and waist circumference.

Broad, discrete categories like obesity, overweight, normal weight and underweight, or high liver fat / low liver fat, group individuals with little resemblance to one another. This lacks the accuracy and precision for appropriate metabolic disease identification and management and removes the individualized perspective. In this webinar, the speakers introduce a more effective tool to manage metabolic disease states — body composition profiling with MRI.

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Currently, among adiposity-related biomarkers, BMI is recommended to identify individuals at increased risk of coronary heart disease and related comorbidities such as Type 2 Diabetes. A high BMI correlates with future health risks and predicts morbidity and death on a population scale. However, it is not effective on an individual scale. Recent research has linked specific fat distributions to adverse cardiometabolic health outcomes, diabetes and liver disease, something that BMI fails to fully describe. In addition, there is heterogeneity in the manifestation of abdominal fat deposits such as liver, visceral and subcutaneous fat. Skeletal muscle is another important identifier in metabolic disease states. Both fatty infiltration and lean muscle volume, or lack thereof (e.g., sarcopenia) are more commonly associated with aging and advanced disease states.

But such specific body composition and fat distributions are not assessable using BMI. They can, however, be effectively and precisely described using magnetic resonance imaging (MRI)-based body composition profiling. Body composition profiling, greatly individualizes the description of the individual, identifying potential hidden health risks and bringing us one step closer to precision medicine related to both assessment and targeted interventions. In this webinar, the featured speakers — clinical and imaging experts — will review the latest research on the impact of different body composition profiles on metabolic health, disease risk and metabolic disease treatment and development. There will be a special focus on the biologic and clinical perspectives, including why body composition matters and how it can be used to guide treatment.

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Join this webinar to gain insights into body composition profiling with MRI, how such measurements have been used in recent research and the recent advancements that have made MRI-based body composition profiling available for clinical use nowadays.

Speakers

http://Carla%20Prado,%20University%20of%20Alberta,%20Canada

Carla Prado, PhD, RD, Professor of Human Nutrition, University of Alberta, Canada

Dr. Carla Prado is a Professor at the University of Alberta in Canada and a Campus Alberta Innovate Program (CAIP) chair in nutrition, food and health. She is also the Director of the Human Nutrition Research Unit. She is an expert in assessing nutritional status through the precise measurement of body composition and energy metabolism.

The focus of her current research program is to develop targeted nutrition interventions for the prevention and treatment of low muscle mass in patients with cancer. She is currently the Principal Investigator for three clinical trials investigating the impact of nutrition intervention on body composition and health.

She is an editorial board member of Clinical Nutrition, the Journal of Cachexia, Sarcopenia and Muscle and Current Opinion in Clinical Nutrition and Metabolic Care.

Dr. Prado is a past recipient of Canada’s Top 40 Under 40, an award that celebrates exceptional young Canadian leaders of all sectors, and she was recently inducted into the Royal Society of Canada, the highest academic honor in her country.

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http://Ian%20J.%20Neeland,%20Case%20Western%20Reserve%20University

Ian J. Neeland, MD, Director of Cardiovascular Prevention and Co-Director of the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease, University Hospitals; Associate Professor of Medicine, Case Western Reserve University

Ian J. Neeland, MD, is Director of the University Hospitals Center for Cardiovascular Prevention, Director of the Translational Science Unit, and Co-Director of the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease (CINEMA program) for University Hospitals Harrington Heart & Vascular Institute and Associate Professor of Medicine at Case Western Reserve University School of Medicine in Cleveland, Ohio. He is a General and Preventive Cardiologist with special expertise in obesity, diabetes and prevention of cardiovascular disease.

Dr. Neeland is a Fellow of the American Heart Association and American College of Cardiology and serves on several national committees with the American Heart Association. He is an active Clinical and Translational Investigator with funding from the National Institutes of Health and industry. He has published over 110 scholarly articles and delivered a number of national, international and regionally invited lectures. He is a reviewer for many respected journals, including Circulation, for which he currently serves as an Associate Editor and Section Editor for Bridging Disciplines.

Message Presenter
http://Mikael%20F.%20Forsgren,%20AMRA%20Medical

Mikael F. Forsgren, PhD, Senior Scientist, Liver Disease Lead Scientist, AMRA Medical

Mikael Forsgren is the Lead Scientist for liver diseases at AMRA Medical with the responsibility of developing and leading liver disease application projects. He has been involved in liver-related research using magnetic resonance (MR) imaging and spectroscopy since 2009 — both in academia and industry. He has a MSc in biotechnology and PhD in medical sciences. In his doctoral thesis he explored MR methods to replace the liver needle biopsy and quantify liver function. In addition to exploring body composition in liver diseases, he has applied his MR expertise to assess body composition in COPD, fibromyalgia syndrome and in general populations. Prior to joining AMRA in 2017 he worked as a consultant for Wolfram MathCore, where he collaborated with several pharma companies, academic institutions and the US Food and Drug Administration. He currently holds an adjunct position at Linköping University and is a member of the university’s Center for Medical Image Science and Visualization.

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Who Should Attend?

Professionals, physicians, clinicians and medical doctors in healthcare, clinical trials, clinical operations, data management and business development including:

  • Cardiologists, Osteopathic Physicians / DO, Gastroenterologists, Hepatologists, Radiologists, Endocrinologists
  • Imaging Specialist
  • Chief Medical/ Executive Officer
  • Principal Investigator
  • Research Nurse
  • Clinical/ Medical Director
  • Clinical Project Manager
  • Clinical Development Manager
  • Physical/ Occupational Therapist
  • Procurement Manager
  • Statistician/ Data Manager
  • Regulatory Coordinator

What You Will Learn

Attendees will learn:

  • The impact of different body composition profiles on metabolic health, disease risk and metabolic disease treatment and development
  • How body composition can be used to guide treatment

Xtalks Partner

AMRA

AMRA Medical is a digital health company at the forefront of medical imaging and precision medicine. The company has developed a new global standard in body composition analysis, delivering multiple fat and muscle biomarkers with unrivaled accuracy and precision – all from a rapid whole-body MRI scan.

AMRA offers medical device and medical research services to support transformative care and vital decision-making, from clinical research to clinical care.

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