Automation Engineer II

BigHat Biosciences

Posted on: September 1, 2026

Closing: October 01, 2026

Salary: 150,000.00 - 168,000.00 per year

Position Type: Full Time

Job Description

Automation Engineer II

Department: Lab Science

Employment Type: Full Time

Location: San Mateo, CA

Description

The role: BigHat Biosciences is seeking a highly motivated Automation Engineer II to join our growing team. This position will support the development and scaling of automated workflows within BigHat's state-of-the-art antibody engineering platform.

Key Responsibilities
  • Lead and contribute to the end-to-end development of high-throughput automated assay processes, spanning a variety of technologies within drug and antibody discovery.
  • Program a variety of laboratory automation instruments and robotic systems.
  • Contribute to the design and development of BigHat's integrated workcells, with an eye for orders-of-magnitude capacity increase, cost reduction, and increased reliability.
  • Lead troubleshooting efforts, analyze existing workflows, identify bottlenecks, and develop innovative solutions geared for robustness and capacity.
  • Collaborate with software engineering and LIMS teams on building and implementing end-to-end integrated workflows leveraging BigHat's cutting-edge software stack.
  • Support equipment validation and qualification efforts, including design, execution, and documentation.
  • Contribute to the growth of the automation team, know-how, and expertise at BigHat.

Skills Knowledge and Expertise
  • BS or MS degree in engineering or science in engineering, biochemistry, or related scientific field, with 2+ years of relevant industry experience.
  • Experience programming or operating automated liquid handling systems, from conception through all phases of development and implementation. Experience with Hamilton and/or OpenTrons platforms preferred but not required.
  • Experience with standard molecular biology and cell biology techniques and/or experience automating drug discovery processes preferred.
  • Functional knowledge in experimental design, bench execution, process documentation, and data analysis.
  • Strong communication skills, and ability to work with people of diverse backgrounds (protein scientists, research associates, data scientists, software engineers, etc.) to scope, develop, and implement solutions.
  • Thrives in a fluid, dynamic start-up environment and enjoys building capabilities from the ground up.

Total Rewards

The salary estimated for this position is $150,000 - $168,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

BigHat Biosciences

Posted on: September 1, 2026

Closing: October 01, 2026

Salary: 150,000.00 - 168,000.00 per year

Position Type: Full Time

Career Focus: Engineer

This role is part of a curated selection of life science opportunities featured on Xtalks. Employers may request edits or removal here.

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