Osteal Therapeutics is a Dallas-based, privately held biotechnology company redefining the standard of care for life-altering orthopedic infections.

Osteal is hiring to launch NEXCHANGE™ KIT, a first-of-its-kind FDA Breakthrough Therapy for periprosthetic joint infection (PJI), a critical condition impacting 50,000 Americans annually. PJI currently lacks FDA-approved therapies and forces patients through grueling, months-long treatments with poor outcomes. Our disruptive technology transforms this journey by safely delivering high-concentration, broad-spectrum antibiotics directly to the infection site; reducing the treatment timeline from months to just seven days.

Powered by $137M in funding to date and a distinguished investor base that includes strategic partners Johnson & Johnson and Zimmer Biomet, we are advancing toward FDA approval and building the organization that will bring this therapy to patients in dire need.

We are looking for bold, relentless professionals who thrive in a "builder" environment. If you are driven by the opportunity to do work that genuinely matters - to be part of a cohesive and capable team striving to deliver the first on-label PJI treatment that promises to transform outcomes for tens of thousands of patients.

About The Role

As our first dedicated HR leader, you'll partner directly with the CEO and leadership team to build and scale the people function. You'll focus on the full employee experience-from attracting top talent to designing the organizational strategy that supports high performance and a strong culture. This is a hands-on role, ideal for someone who thrives in dynamic environments and loves building from the ground up.

Responsibilities

Essential functions of the position include but are not limited to the following. Other duties may be assigned.

• Talent Acquisition: Build and run scalable recruiting strategies that attract diverse, mission-driven talent.
• Talent Management: Develop career pathing, growth frameworks, and development initiatives for all levels.
• Performance Management: Design and implement a performance management process that supports clarity, feedback, and accountability.
• Culture & Engagement: Champion a culture of ownership, collaboration, and purpose. Drive engagement strategies that keep people motivated and connected.
• Employee Relations: Serve as a trusted resource for employees and managers, navigating sensitive topics with discretion and care.
• Organizational Design & Strategy: Partner with leadership on team structure, scaling plans, and future-state org design.
• Leadership Development: Coach managers and help grow leadership capabilities across the team.

Requirements

• Bachelor's degree in a related field required.
• 6+ years of progressive HR experience, with experience in a startup or fast-growing environment strongly preferred.
• Strong background in talent acquisition, employee development, and culture-building.
• Comfortable being both strategic and hands-on.
• Experienced in supporting a scaling company as it moves from early stage to growth.
• A trusted partner and clear communicator who can influence at all levels.
• Passionate about building inclusive and high-performing teams.
• Experience with recruitment technology and applicant tracking systems (ATS).
• Strategic thinking and problem-solving skills.

Preferred Qualifications

• Excellent communication, collaboration, and interpersonal skills.
• Ability to prioritize tasks and manage multiple projects effectively.
• Hands-on, driven work ethic and entrepreneurial spirit.

Our Benefits

• 100% of Health Insurance paid by OstealTx for Employee & Dependents
• Dental & Vision Insurance
• Short & Long Term Disability Insurance paid 100% by OstealTx
• 401k (Regular & Roth)
• Holiday Pay & PTO
• Competitive compensation: Base ($180,000 -$200,000) + Bonus + Equity

Osteal Therapeutics is an Equal Opportunity Employer. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to protected characteristics such as race, color, religion, sex, national origin, age, disability, or veteran status.