The Ranish Group is seeking a highly motivated Postdoctoral Fellow to conduct research investigating

the transcriptional regulatory mechanisms underlying hematopoietic stem cell differentiation and how

defects in the process lead to diseases such leukemia and b-thalassemia. To accomplish this goal, the lab

is developing mass spectrometry-based technologies to quantify the transcription factor proteome in

purified populations of differentiating erythroid cells. The data is being integrated with other

transcription-relevant -omics data to model the transcriptional regulatory networks underlying

hematopoiesis. The models are then used to guide experiments to understand how specific transcription

factors drive cell fate decisions. The successful applicant will be expected to design, execute, analyze,

and troubleshoot the experiments.

This position is contingent upon funding expected to be received around July 2026.

Key responsibilities include

• Development and application of mass spectrometry-based proteomics technologies
• Recombinant protein expression and purification
• Molecular biology assays
• Discuss and present research at internal meetings
• Manuscript preparation

Qualifications:

• PhD in analytical chemistry or biomedical sciences (i.e., molecular/cellular biology or

biochemistry)

• Strong interest in mass spectrometry-based proteomics and gene regulation
• Ability to organize and prioritize work, work efficiently and independently
• Strong verbal and written communication skills

All ISB staff members are expected to have baseline technical skills and the ability to communicate

effectively and appropriately over email, the intranet/forum, etc. Employees should be able to use

Word, Excel, Outlook and PowerPoint at a functional level.

Benefits information: https://isbscience.org/careers/benefits/

Expected annual pay is $80,169

ISB is a D/V/EOE.