Poseida is at the forefront of cancer therapy with its novel and robust approach to chimeric antigen receptor (CAR) T-cell therapy. Our platform for allogeneic CAR-T cells can potentially deliver life-saving treatments to patients consistently and quickly. Critical to that mission is understanding the factors that define good and bad donors, as well as good and bad CAR-T lots. As part of our team in Immuno-Oncology, you will use a multitude of analytical approaches to class donors for clinical use across all of Poseida’s CAR-T programs. Further, we will use this data as the foundation to improve CAR-T efficacy. Success in this effort would greatly enable Poseida’s ability to rapidly deliver CAR-T therapies to those patients in need. Come join our team and help make allogeneic CAR-T therapy a reality!

Position Summary:

Poseida is seeking an outstanding candidate to join our Immuno-Oncology team, whose mission is to identify healthy donors to advance to clinical manufacturing of allogeneic CAR-T cells. The Research Associate will support these efforts by: (1) characterizing CAR-T cells for their phenotype and functionality both in vitro and in vivo; (2) characterizing primary lymphocytes; and (3) managing the inventory of primary lymphocytes for both this program and the department’s wider preclinical research. The position will involve bench work, data analysis and interpretation, and inventory of cells and biological samples with the assistance of your manager.

Responsibilities 

These may include but are not limited to:

• Support preclinical research and the evaluation of T cells, and their resulting CAR-T cells, for their manufacturability and downstream efficacy as CAR-T cells through flow cytometry and in vivo analysis
• Analyze and interpret data to assess T cell quality, health, and efficacy in a data-driven holistic approach
• Organize and maintain lymphocyte, and other raw material, inventory through electronic documentation
• Other lab work may include: molecular biology and cloning, tissue culture of human cell lines, and isolation of cells from blood products
• Communicate experimental results and issues in a concise and timely manner to colleagues.

Requirements, Knowledge, Skills and Abilities:

• Master's or Bachelor's degree in a scientific discipline with Research Associate: 0 to 2 plus years; Research Associate II: 2 to 5 years relevant experience in the field of immunology, molecular biology, or related field (an equivalent combination of education and experience may be considered)
• Proficiency in multi-parameter flow cytometry and FACS data analysis via FlowJo is preferred
• Aseptic cell culture technique
• Experience with the characterization, expansion, and manipulation of T cells or CAR-T is preferred
• Excellent record keeping & data management skills required.
• Ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds
• Excellent communicator with track record of working effectively as an individual contributor and in teams

Research Associate Pay Rate: $32.21/hour to $36.00/hour

Research Associate II Pay Rate:  $36.54/hour to $42.00/hour

The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.

Who We Are and What We Do 

Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients’ lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.