Description

Scientist, Analytical Development and Mass Spectrometry

Position Overview
Sutro Biopharma, Inc. is looking for a Scientist to join our Analytical Development group to support chromatography and mass spectrometry analyses for antibodies (mAb), bispecific antibodies (bsAb), antibody drug conjugates (ADCs), immunostimulatory antibody drug conjugate (iADCs) and cytokine derivatives.

Responsibilities

• Develop chromatography assays for testing of recombinant proteins such as antibody derivatives
• Develop mass spectrometry assays for testing of recombinant proteins such as antibody derivatives
• Process and interpret data from assays to communicate and present to internal and external colleagues
• Author and review SOPs, protocols, and technical reports
• Act as Subject Matter Expert for chromatography and/or mass spectrometry for the analytical group.
• Perform routine chromatography and mass spectrometry testing to support analytical upstream, downstream, and formulation process development teams.
• Qualify assays and support technology transfer to Sutro QC, and to partner and contract testing laboratories
• Work with moderate supervision while also working collaboratively within the Analytical group and across functional groups.
• Contribute to product characterization studies.
• Communicate data both verbally at group meetings and through written documents and reports.
• Engage collaboratively within Analytical Development, other functional areas, external partners, and CMOs
• Perform routine maintenance and troubleshoot HPLCs and other separations-based instrumentation

Qualifications:

1. Ph.D. in scientific discipline with 1-6+ years' experience, or BS/MS in analytical chemistry, biochemistry, molecular biology or related scientific field and 8+ years of industry experience in the characterization of large molecule biologics is required
2. Experience with operating and maintaining of HPLCs/UHPLCs and mass spectrometry instrumentation is highly preferred
3. Proficiency with data processing software such as Chromeleon, OpenLab ChemStation, or Empower is preferred
4. Understanding of some separation methods (Protein A/G/L, RP, IEX, SEC, HIC, HILIC) is preferred.
5. Experience with method development, qualification, and method transfer to a QC environment is a plus
6. Knowledge of alternative detection modules such as FLD, MALS, ELSD, and/or CAD is a plus
7. Knowledge of additional analytical techniques such as iCIEF, mCE-SDS (Caliper), and/or CE-SDS is a plus
8. Flexibility to work on multiple projects and communicate effectively in a fast-paced environment is essential

Sound exciting? Apply today and join our team!

Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.

As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.

We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies.

The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma's California based locations will be $117,000 - $139,000 (not including bonus, equity, and benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.

About Sutro Biopharma

Sutro Biopharma, Inc. is advancing a next-generation antibody-drug conjugate (ADC) platform designed to deliver single- and dual-payload ADCs that enable meaningful breakthroughs for patients with cancer. By fully optimizing the antibody, linker, and payload, Sutro's cell-free platform produces ADCs that are engineered to improve drug exposure, reduce side effects, and expand the range of treatable tumor types. With unique capabilities in dual-payload ADCs, Sutro aims to overcome treatment resistance and redefine what's possible in cancer therapy. The Company's pipeline of single- and dual-payload ADCs targets large oncology markets with limited treatment options and significant need for improved therapies.