About the role:

We are seeking a highly motivated and intellectually agile Scientist to join our stealth-mode biotech company and contribute to programs focused on hematopoietic cell biology. This laboratory-based role will be responsible for designing, executing, and interpreting in vitro experiments that generate actionable insights and support scientific decision-making.

The successful candidate will be mechanistically minded, able to connect experimental observations to underlying biology, build novel reproducible assays, and deliver results in a fast-paced environment.

The position is a rare opportunity to play a pivotal role in the successful development of new drugs for patients within an early-stage therapeutics company backed by highly regarded investors.

Key Responsibilities:

• Lead efforts to develop a novel therapeutic for the treatment of a hematologic disease with unmet medical need
• Develop, optimize, and perform cell-based assays to evaluate the impact of compounds on:
• Erythroid differentiation (e.g., flow cytometry markers,morphology)
• Cell health (e.g., viability)
• Protein-level readouts (e.g., flow cytometry, ELISA, high content imaging, Western blot)
• RNA-level outcomes (e.g., qPCR)
• Culture and differentiate multiple cell lines using established and custom protocols.
• Collaborate with scientists, mentor and train associates in a small biotech startup environment.
• Translate and develop selected assays to support in vivo pharmacology studies.
• Maintain detailed laboratory records, perform data analysis, and present findings in team meetings.
• Ensure compliance with all lab safety, quality, and recordkeeping standards.
• Oversee research activities with external research organizations (CROs) as needed

Qualifications:

• PhD in Cell Biology, Molecular Biology, or a related field with 0-2 years of industry experience preferred
• BS or MS in Cell Biology, Molecular Biology, or a related field with 5+ years of relevant industry research experience will be considered
• Proven tissue culture experience with human cell lines and primary human cell culture-ideally CD34+ hematopoietic or other stem/progenitor cells. Familiarity with erythroid differentiation assays and hematopoietic biology is a plus.
• Molecular biology expertise including DNA and RNA purification and practical expertise with downstream nucleic acid-based (e.g., qPCR, and RNA-seq) and protein-based assays (e.g. flow cytometry, ELISA, and Western blotting)
• Demonstrated experience in building novel cell-based assays is a strong plus.
• Excellent attention to detail, organizational skills, and ability to work both independently and collaboratively.
• Excellent problem-solving skills and a track record of learning new techniques and scientific concepts quickly.
• Strong communication skills for cross-functional teamwork and clear documentation.

What we offer:

• Competitive compensation and benefits
• A collaborative, small-team environment with growth opportunities
• The opportunity to contribute to innovative drug discovery efforts and join an early-stage biotechnology company backed by highly regarded investors

Location: Cambridge, MA