Bigger, Better, Faster: New Tools for Chemical Protein Synthesis

Life Sciences, Laboratory Technology,
  • Friday, November 13, 2020

The Kay lab at the University of Utah is focused on D-peptide inhibitor development, which requires the chemical synthesis of mirror-image protein targets. This webinar will describe the use of recently developed chemical and computational tools to accelerate chemical protein synthesis of large proteins. Specific topics will include recently developed next generation “helping hand” traceless linkers to improve peptide solubility, the use of traceless templating to accelerate ligations, and their automated ligator program (Aligator) for prediction of the optimal synthetic routes.

Speaker

http://Michael%20S.%20Kay,%20Utah%20School%20of%20Medicine

Michael S. Kay, Professor Biochemistry, University of Utah School of Medicine

Michael Kay is an H.A. and Edna Benning Presidential Endowed Chair Professor of Biochemistry in the University of Utah School of Medicine. He is Director of the Biological Chemistry Graduate Program and Utah’s Chemical Biology NIH Training Grant. Before coming to Utah in 2001, he trained with Harold Scheraga at Cornell University (BA in Biology and Chemistry), Robert Baldwin at Stanford University (MD/PhD in Biochemistry), and Peter Kim at MIT (Damon Runyon Postdoctoral Fellow). His lab designs mirror-image peptides for use as novel therapies that are not degraded in the body, with a special emphasis on viral entry inhibitors.

Message Presenter

Who Should Attend?

  • Scientist, Senior Scientists, Technical Leaders
  • Researchers, PhD Candidates, Post-Doctoral Researchers
  • Researchers Involved in Peptide Therapeutics or Peptide Synthesis

What You Will Learn

In this webinar, participants will learn about how:

  • “Helping hand” traceless linkers are a valuable tool for solubilizing difficult peptide segments
  • Templated ligations greatly accelerate ligations and can rescue otherwise suboptimal ligation junctions
  • Computational simulation of potential chemical protein synthesis routes can be used to predict optimal synthesis strategies

Xtalks Partner

Gyros Protein Technologies

Gyros Protein Technologies enables peptide synthesis and bioanalytical solutions that help scientists increase biomolecule performance and productivity in research, drug discovery, pre-clinical and clinical development, and bioprocess applications. Our low to mid-scale peptide synthesizer platforms are the Tribute®, Prelude® X, Symphony® X, and Sonata®. These solutions and our chemistries deliver uncompromising purity, flexibility, and quality for discovery and pre-clinical studies of simple to complex multifunctional peptides. Proprietary high performance nanoliter-scale immunoassay platforms, Gyrolab® xPand, Gyrolab® xP workstation and Gyrolab xPlore™, are used by scientists in leading pharmaceutical, biotech, CRO, and CMO companies for bioanalytical applications such as pharmacokinetics/pharmacodynamics, immunogenicity, and quantitating bioprocess-related impurities. Our peptide synthesis and bioanalytical solutions accelerate your discovery, development, and manufacturing of safer biotherapeutics.

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