The Kay lab at the University of Utah is focused on D-peptide inhibitor development, which requires the chemical synthesis of mirror-image protein targets. This webinar will describe the use of recently developed chemical and computational tools to accelerate chemical protein synthesis of large proteins. Specific topics will include recently developed next generation “helping hand” traceless linkers to improve peptide solubility, the use of traceless templating to accelerate ligations, and their automated ligator program (Aligator) for prediction of the optimal synthetic routes.
Michael S. Kay, Professor Biochemistry, University of Utah School of Medicine
Michael Kay is an H.A. and Edna Benning Presidential Endowed Chair Professor of Biochemistry in the University of Utah School of Medicine. He is Director of the Biological Chemistry Graduate Program and Utah’s Chemical Biology NIH Training Grant. Before coming to Utah in 2001, he trained with Harold Scheraga at Cornell University (BA in Biology and Chemistry), Robert Baldwin at Stanford University (MD/PhD in Biochemistry), and Peter Kim at MIT (Damon Runyon Postdoctoral Fellow). His lab designs mirror-image peptides for use as novel therapies that are not degraded in the body, with a special emphasis on viral entry inhibitors.
Who Should Attend?
- Scientist, Senior Scientists, Technical Leaders
- Researchers, PhD Candidates, Post-Doctoral Researchers
- Researchers Involved in Peptide Therapeutics or Peptide Synthesis
What You Will Learn
In this webinar, participants will learn about how:
- “Helping hand” traceless linkers are a valuable tool for solubilizing difficult peptide segments
- Templated ligations greatly accelerate ligations and can rescue otherwise suboptimal ligation junctions
- Computational simulation of potential chemical protein synthesis routes can be used to predict optimal synthesis strategies
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