Drug Discovery Beyond Rule of Five: ECCS Class 3 and 4 Strategies

This webinar will provide practical strategies for designing and advancing beyond rule-of-five (bRo5) drug candidates, with a focus on class 3 and class 4 extended clearance classification system (ECCS) compounds.

Attendees will gain a deeper understanding of how to address key challenges in permeability, metabolism and cellular uptake, which are common hurdles in this complex chemical space.

The presentation will explore the use of modified in vitro assays and physicochemical design principles to better guide decision-making in early discovery. It will also highlight how innovative medicinal chemistry and algorithms can be applied to improve success rates for compounds that fall outside traditional drug-like parameters.

For those working on large, polar molecules or looking to optimize difficult scaffolds, this session will offer valuable insights for improving developability and reducing attrition in early-stage programs.

Register for this webinar to learn how to confidently progress bRo5 compounds from concept to candidate.

Speaker

Philippe McGee, Principal Scientist, X-Chem

Since joining X-Chem in 2019, Phil has focused on designing medicinal chemistry strategies for chemotypes in the bRo5 space, bifunctional and non-bifunctional, across multiple protein targets and indications. These strategies go beyond optimization of metabolism and into controlling biliary or renal elimination. Phil has a PhD from the University of Ottawa, where his research focused on the application of metal-catalyzed reactions towards the synthesis of polycyclic natural products.

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