Exploratory Pathology in Action: Advancing Nonclinical Drug Development Across Therapeutic Areas

Exploratory pathology leverages the knowledge and expertise of comparative medicine, pathological processes and biomedical research activities to understand mechanisms of disease and disease pathogenesis and help guide the evaluation and potential impact of treatments on health and disease progression.

This webinar will provide a comprehensive overview of how exploratory pathology can provide the scientific expertise across multiple phases of drug development. Examples of how exploratory pathology contributes to early discovery, lead optimization and exploration of pathogenic mechanisms and how to address challenges across multiple therapeutic modalities will be discussed.

Attendees will also learn the importance and value of incorporating exploratory pathology components in their nonclinical drug development programs across multiple therapeutic areas, including neuropathology, immunopathology, ocular pathology and medical devices.

Register for this webinar today to learn how exploratory pathology can provide key pathologic data advance nonclinical drug development programs across discovery and safety assessment.

Speakers

Tracey L. Papenfuss, DVM, PhD, MS, DACVP, Senior Pathologist, StageBio

Tracey L. Papenfuss is a veterinary pathologist and immunologist with over 20 years of experience developing and evaluating immunotherapies in academic and industry. Tracey has worked across multiple sectors (discovery to safety assessment) in drug and immunotherapy development and employs exploratory pathology to help evaluate therapies and support the development of new therapies that impact human and animal health.

Tracey is currently a Senior Pathologist at StageBio where she focuses on the immunosafety space and provides immunopathology expertise. Prior to her current position, she was a research faculty member that led an exploratory (discovery) immunology research laboratory that evaluated novel immunotherapies for the treatment of cancer and both autoimmune and inflammatory diseases and was a toxicological pathologist working on multiple species in the nonclinical drug development space at Charles River Laboratories.

Dr. Papenfuss earned her DVM from the University of Minnesota and completed her Anatomic Pathology residency and training at the Ohio State University. Dr. Papenfuss holds an MS and PhD degree in immunology and is a board-certified veterinary pathologist. She is an active member of the Society of Toxicologic Pathologists (STP), Society of Toxicology (SOT), American College of Toxicology (ACT), American College of Veterinary Pathologists (ACVP) and the Health and Environmental Sciences lmmunosafety Technical Committee (HESI-ITC) and maintains an adjunct faculty appointment at Ohio State University. She has authored or co-authored numerous peer-reviewed publications and book chapters and has been invited to present on topics of immunology, pathology, immunotherapies and related topics nationally and internationally.

Message Presenter

Stephanie M. Shrader, DVM, PhD, DACVP, Vice President of Pathology Solutions, StageBio

Stephanie M. Shrader is a Veterinary Pathologist with a broad background in nonclinical toxicologic pathology and over 10 years of experience focusing on ocular pathology in both academia and industry. Stephanie has worked across multiple sectors (discovery to safety assessment) in ocular drug and medical device development and employs exploratory pathology to help evaluate therapies and support the development of new therapies that impact human and animal health.

Stephanie is currently the Vice President of Pathology Solutions at StageBio where she oversees StageBio’s US-based pathology, necropsy and research associate teams. She also continues to serve as a Study Pathologist with expertise in ocular pathology. In previous positions, she served as a Toxicological Pathologist working on multiple species in the nonclinical drug development space at Charles River Laboratories and was a Clinical Lecturer at Auburn University College of Veterinary Medicine.

Dr. Shrader earned her DVM from the Virginia Maryland Regional College of Veterinary Medicine and completed her Anatomic Pathology residency and training at Auburn University College of Veterinary Medicine. Dr. Shrader holds a PhD degree in Biomedical Sciences and is a board-certified Veterinary Pathologist. She is an active member of the Society of Toxicologic Pathologists (STP), Society of Toxicology (SOT), American College of Toxicology (ACT), and American College of Veterinary Pathologists (ACVP). She has authored or co-authored numerous peer-reviewed publications and book chapters and has been invited to present on topics of ocular pathology, neuromuscular diseases and general toxicologic pathology.

Message Presenter