In this webinar, the speakers will showcase the selection and optimization of long-acting microsphere formulations with releases ranging from weeks to one year.
The speakers will discuss the chemistry of lactide/glycolide-based bioresorbable polymers applied to various parenteral formulations and a microsphere technology platform that offers reproducible, scalable and consistent critical quality attributes under current good manufacturing practices (cGMP) for multiple therapeutic indications.
They will explain the chemistry, key characteristics and versatility of lactide/glycolide polymers and show how challenges in controlled drug release formulations and medical devices can be solved. They will also introduce their NEW viatel™ Ultrapure polymer grades and detail the advantages of ultra-low residual monomer specifications.
The speakers will also present two microsphere case studies: (1) a peptide formulation development with varied release needs and (2) a small molecule active pharmaceutical ingredient (API) from formulation development through scale-up, highlighting common scale-up challenges and solutions. These case studies showcase how varying process parameters and polymer chemistries based on lactide and glycolide make it possible to optimize drug load, release duration, particle size and encapsulation efficiency.
Register for this webinar on long-acting injectables to learn about the selection and optimization of long-acting microsphere formulations with releases ranging from weeks to one year.
Speakers
Patrick Duffy, R&D Team Leader, Ashland
Patrick Duffy is the R&D Team Leader for the viatelTM bioresorbable polymer portfolio at Ashland and is responsible for all research and development activities relating to this product line. He also supports customers with technical solutions in the development of extended-release parenteral drug delivery formulations, medical devices, tissue engineering scaffolds and cosmetics.
Patrick obtained his BEng, MSc and PhD from University College Dublin (UCD), Ireland, and joined Ashland as part of the Vornia Ltd. acquisition in 2018 where he previously held responsibility for both R&D and production of bioresorbable polymers. During his time at Vornia, he played a key role in the development of the company’s major intellectual property platform for production of bioresorbable polymers.
He has extensive knowledge of bioresorbable polymer design, chemistry and processing technologies used in medical applications, and has authored or co-authored several research/review articles on these topics.
Message Presenter
Rachel Minrovic, R&D – Formulations, Oakwood Laboratories
Rachel Minrovic is currently a Formulation Engineer in the Research and Development group at Oakwood Laboratories, L.L.C. (Cleveland, Ohio, USA).
Rachel received her Bachelor of Chemical Engineering from the University of Dayton (Dayton, Ohio, USA) where she performed research in developing cell-based in vitro silver nanoparticle pharmacokinetic profiles in efforts to bridge the in vitro-in vivo gap.
She joined Oakwood Labs in 2019 and is now involved in furthering the development and production of microsphere products and advancements in microsphere process technology, which have culminated in several patent filings. She currently works as the team leader of multiple projects involving the encapsulation of various active pharmaceutical ingredients (API) into biodegradable polymeric microspheres.
These injectable microspheres, for both human and animal use, can extend the efficacy of APIs for as long as one week and up to one year in vivo.
Who Should Attend?
This webinar will appeal to those in the following fields or with the following job titles:
- Pharmaceutical companies
- Formulators
- Scientists
- R&D Engineers
- Process Engineers
- Plant Managers
- QA and QC personnel
What You Will Learn
Attendees will learn about:
- The polymer chemistry of viatel™ and critical quality attributes that can help achieve tunable release profiles in long-acting drug formulations
- The development and scale up challenges that can be approached and overcome using Chroniject™ technology
- Strategies in microsphere technology that can be coupled with appropriate bioresorbable polymers
Xtalks Partner
Ashland
Ashland’s pharma business is well known for acetylenics, cellulosics, and film coatings, and their polymers have a rich and diverse history supporting active pharmaceutical ingredient delivery. Deploying resources to build on their existing high impact and high value technologies, they are widening their portfolio of cellulose-based polymers (HPMC, HPC, CMC, HEC, EC), growing their excipient portfolio for injectables/biologics, including the possibility for customization, and they’re focusing on film coatings that live up to customer needs.
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