Overcoming Challenges in Pediatric Clinical Trials With Digital Devices

It is notoriously difficult to conduct studies with cohorts of young children and their caregivers. The collection of accurate data from pediatric clinical trials suffers from both subjectivity in patient-reported outcomes and high dropout rates due to heavy patient burden. The decentralization of certain trial components represents a step in the right direction. But much remains to be done if this busy cohort is expected to raise their hands for participation.

This webinar discusses methods to mitigate the many challenges that are characteristic to pediatric clinical trials. Panelists will share their recent experiments that use artificial intelligence (AI) and image and audio capture to lighten patient burden. They will share the results of recently published research comparing caregiver and expert ratings to reduce bias in outcomes measurement in pediatrics and beyond. Attendees will have a front row seat to the future of pediatric clinical research that is just around the corner.

Join this webinar as pediatric researchers, clinical practitioners and digital technology experts discuss the new technologies for clinical trials. These new technologies are creating a virtuous cycle between patient-centric clinical trials and real-world impacts in clinical practice.

Speakers

Jaya Punati, MD, Medical Director, Pediatric Colorectal and Pelvic Malformation Center, Associate Director of Clinical Operations, Children’s Hospital of Los Angeles (CHLA)

Jaya Punati, MD, is a board-certified pediatric gastroenterologist with more than 25 years of experience in the medical field. After graduating from Gandhi Medical College in 1997, Dr. Punati completed her residency in pediatrics at Morristown Memorial Hospital, University of Medicine and Dentistry of New Jersey (UMDNJ). Following her residency, she fulfilled two fellowships at the Nationwide Children’s Hospital — one in pediatric gastroenterology and one in pediatric neurogastroenterology and motility. She now serves in several roles at the Children’s Hospital of Los Angeles (CHLA), where she specializes in pediatric colorectal and gastrointestinal motility disorders. Her recent awards and achievements include being named one of the “Top Doctors” in the Gastroenterology and Nutrition category by Pasadena Magazine.

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Brian Cohn, PhD, Director of Research, ObvioHealth

Brian Cohn, PhD, is a computational biologist specializing in the development and application of creative digital solutions in healthcare. With a foundation in data-driven biomedical science, Dr. Cohn’s portfolio of work includes the design and deployment of medical devices, the study of human and vertebrate biomechanics and AI-driven digital instruments. He currently serves as the Director of Research at ObvioHealth, where he leads multiple research teams in studying pediatric outcome devices. His work has included AI analyses of pediatric stool, biochemical test interpretation and automated audio characterization of coughs. In conjunction with this work, Dr. Cohn is a Visiting Scientist at the Children’s Hospital of Orange County. Dr. Cohn holds a PhD in Computer Science from the University of Southern California and is an NSF Graduate Fellow.

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Susan Dallabrida, PhD, Chief Executive Officer, SPRIM Global

For more than 25 years, Susan Dallabrida, PhD, has served as a leader in clinical trials, healthcare, and eClinical technology for biopharmaceutical and health-related consumer goods companies. Dr. Dallabrida is an expert in clinical innovation, specializing in rater and patient training, the collection of real-world data in decentralized clinical trials, as well as ePRO, ClinRo, and instrument development and validation. Her career began at Harvard Medical School, where she served as Principal Investigator and Lab Director at the Children’s Hospital before transitioning into new roles with Biogen, ERT, Oracle Health Sciences and SPRIM Global. Dr. Dallabrida holds a doctorate from Pennsylvania State University, College of Medicine, with a PhD in Biochemistry and Molecular Biology.

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Hawley Linke, PhD, Senior Vice President of Scientific Affairs, ObvioHealth

Hawley K. Linke, PhD, began her training in experimental molecular biology at the Salk Institute, UCLA, and Stanford University School of Medicine. Since then, her career has been devoted to pragmatic applications in the field of healthcare — primarily in pediatric nutrition, illness prevention and enigmatic virus diagnostics. These applications range from exploiting the modification of expressed human genes for large-scale therapeutic proteins to nutrient-based innovation against common infant feeding dilemmas. Dr. Linke has authored several scientific publications, patent applications and grants, as well as a book on viral gene expression. She currently leads ObvioHealth’s Scientific Affairs department where she works to identify and implement contemporaneous, data-driven and innovative clinical strategies.

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