The RNAscope™ in situ hybridization (ISH) assay provides spatial visualization of biodistribution and efficacy of adeno-associated virus (AAV) vector-mediated gene delivery.
Low transduction efficiency, off-target tropism and overcoming pre-existing immunogenicity are some challenges presented when developing AAV-based gene therapeutics. Capsid engineering can improve transduction efficiency, cellular and tissue tropism and overcome immunogenicity. Therefore, the selection of engineered capsids that demonstrate desirable properties is critical to making informed decisions for AAV-based gene therapies.
The RNAscope™ ISH assay guides the selection of the optimal capsid, demonstrates improved and selective transduction of the viral vector to safely deliver cargo intracellularly and improves tissue tropism with functional efficiency as well as persistence over time.
In this webinar, the attendees will also learn about Bio-Techne’s flexible, scalable multi-omic service offerings with expert end-to-end RNAscope™ Professional Assay Services (PAS), including early access to new assay capabilities.
Register for this webinar today to know how capsid engineering and the RNAscope™ ISH assay can dramatically enhance the specificity, efficacy and safety of gene therapies.
Speaker
Sharel Figueredo, PhD, Sr. Manager, Biopharma Business Dev. Spatial Biology Division, Bio-Techne
Sharel Figueredo completed her PhD at University of California, Irvine, and has over 10 years of experience in biotech. She has held positions as a Staff Scientist at ThermoFisher working on ProtoArray services for customers and biomarker assays using mass spectrometry. She has also led Field Applications teams in North America at companies such as Protein Simple and Quanterix and provided customer support for solution-based immunoassays.
Message PresenterWho Should Attend?
This webinar will appeal to:
- Biopharma in gene therapy with AAV
- Biotechs in gene therapy with AAV
- Capsid optimization, vector and transgene biodistribution, functional testing for safety and efficacy
- Directors, Lab Principal Investigators, CEOs and CSOs
What You Will Learn
Attendees will learn about:
- Cellular tropism of the various AAV serotypes in a spatial context
- Detecting AAV vector biodistribution and transgene expression at single-cell resolution
- Enabling visualization of multiple targets with multi-omic analysis
- Accelerate discoveries with Bio-Techne’s Professional Assay Services
Xtalks Partner
Bio-Techne
ACD, a Bio-Techne brand, is a leader and pioneer in the advancement of spatial genomics. Based on proprietary RNAscope™ Technology, the first multiplex fluorescent and chromogenic ISH platform, we enable single-cell RNA detection within a spatial context. Our portfolio includes RNAscope, BaseScope™, miRNAscope™, RNAscope Plus, Multiplex Fluorescent V2 and HiPlex™ v2. With 50,000+ probes and our Professional Assay Services, we enable rapid visualization of unique targets. Launched in 2011, the technology has been cited in 10,000+ articles.
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