Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness
• Financial Wellness
• Support for Caregivers

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us

The Importance of the Role
The Associate Engineer, RNA Starting Material MS&T will work in a team focused on lab-scale organic synthesis, purification, analysis, and characterization of the nucleoside-based and lipid building blocks of Sarepta's phosphorodiamidate morpholino oligomers (PMOs), next-generation PMO, and siRNA platforms. The role will involve both synthesis of reference markers/standards and participating in supervised RNA starting materials manufacturing process chemistry development and scale-up projects to optimize and troubleshoot syntheses. The role will involve cross-functional training, regular interaction with Analytical/QC resources, and interpretation of HPLC, GC, KF, and NMR data. The position involves protocol and report writing and requires excellent organic chemistry and problem-solving skills.

The Opportunity to Make a Difference

• Support commercial supply assurance for RNA starting materials by synthesizing nucleoside reference markers/standards.
• Execute development studies either independently or as part of a team under supervision.
  • Assess scalability of proposed changes and execute experiments to mimic the impacts of operations at large scale.
  • Participate in the Technology Transfer of improved processes to manufacturing sites.
• Cultivate a firm scientific understanding of Sarepta's manufacturing processes to support process improvements, troubleshooting, and technology transfers.
• Perform synthesis and purification (chromatography) of nucleoside analogs to support both production and development goals.
• Contribute to collaborative efforts to characterize and manage the impurity profiles of intermediates.
  • Use scientific judgement to determine likely source and fate of newly identified impurities and design experiments to test hypotheses as part of a cross-functional team.
• Data compilation, data interpretation, documentation of study results, and presentation of data and conclusions.
• Participate in vendor update meetings and provide input on ongoing vendor production projects.

More about You

• B.S. (required) in Chemical Engineering, Chemistry, or related discipline, 0-2 years related experience
• Technical competence in organic chemistry and familiarity with analyzing and interpreting data from GC, LC-MS, HPLC, NMR, and KF instrumentation. Experience running HPLC methods is strongly preferred.
• Able to handle multi-task workload and perform effectively under deadlines
• Effective written and verbal communication skills
• Strong interpersonal skills and attention to detail are necessary
• May require <5% infrequent domestic and/or international travel

What Now?

We're always looking for solution-oriented, critical thinkers.

So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

#LI-Onsite

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This position requires work on site at one of Sarepta's facilities in the United States.

The targeted salary range for this position is $62,000 - $77,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.