Principal Scientist, Computational Biology – Islet Biology

Sana

Posted on: January 23, 2025

Closing: February 22, 2025

Position Type: Full Time

Job Description

  • Partner with the beta islet group to design studies, answer biological questions and analyze cell differentiation data.
  • Derive insights from transcriptomic and other omics datasets, including scRNA-seq, bulk RNA-seq, and snRNA-seq that enable therapeutic development
  • Communicate to a broad audience with a range of technical, analytical, and biological expertise and present results at group meetings
  • Collaborate with Computational Biology and Computational Engineering groups to provide reproducible, tested, and robust analyses

What we’re looking for

    • D. in computational biology, genetics, bioinformatics, statistics, or related discipline with 5+ years of industry or relevant academic experience, or M.Sc. with 10+ years or equivalent combination of education/work experience
    • Domain experience in stem cell differentiation and engraftment experiments, especially islet beta cells or other endocrine cell lineages
    • Knowledge of mammalian cell differentiation and methods to assess purity and stability of iPSC generated cell lines
    • Proficiency in Python and R, Unix/Linux, and HPC systems; familiarity with testing frameworks for assuring code correctness
    • Strong scientific background including an understanding of molecular biology, cell biology, and genomics resources

What will separate you from the crowd 

  • Expertise in generating testable hypotheses from large omics datasets
  • Demonstrated skill in existing single-cell analysis tools such as Seurat, Scanpy, Slingshot, or Monocle for trajectory inference and cell cycle regression
  • Knowledge of workflow languages (Nextflow, CWL) and demonstrated ability to transition analyses into modules/library code for general use in pipelines


What you should know

  • The base pay range for this position at commencement of employment is expected to be between $175,000 and $205,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

How we work together for patients

  • Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
  • Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
  • Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution 

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Sana

Posted on: January 23, 2025

Closing: February 22, 2025

Position Type: Full Time

Career Focus: Analyst, Biology, Scientist

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