Principal Scientist, Computational Biology – Islet Biology
Cambridge, United States
Job Description
- Partner with the beta islet group to design studies, answer biological questions and analyze cell differentiation data.
- Derive insights from transcriptomic and other omics datasets, including scRNA-seq, bulk RNA-seq, and snRNA-seq that enable therapeutic development
- Communicate to a broad audience with a range of technical, analytical, and biological expertise and present results at group meetings
- Collaborate with Computational Biology and Computational Engineering groups to provide reproducible, tested, and robust analyses
What we’re looking for
-
- D. in computational biology, genetics, bioinformatics, statistics, or related discipline with 5+ years of industry or relevant academic experience, or M.Sc. with 10+ years or equivalent combination of education/work experience
- Domain experience in stem cell differentiation and engraftment experiments, especially islet beta cells or other endocrine cell lineages
- Knowledge of mammalian cell differentiation and methods to assess purity and stability of iPSC generated cell lines
- Proficiency in Python and R, Unix/Linux, and HPC systems; familiarity with testing frameworks for assuring code correctness
- Strong scientific background including an understanding of molecular biology, cell biology, and genomics resources
What will separate you from the crowd
- Expertise in generating testable hypotheses from large omics datasets
- Demonstrated skill in existing single-cell analysis tools such as Seurat, Scanpy, Slingshot, or Monocle for trajectory inference and cell cycle regression
- Knowledge of workflow languages (Nextflow, CWL) and demonstrated ability to transition analyses into modules/library code for general use in pipelines
What you should know
- The base pay range for this position at commencement of employment is expected to be between $175,000 and $205,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience
How we work together for patients
- Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
- Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
- Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution
Get to know us
At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.
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