Scientist – Immunoassay and Biomarker Development
Waltham, Massachusetts, United States
Job Description
POSITION SUMMARY:
The Scientist - Immunoassay and Biomarker Development's primary focus is on immunoassay development, screening, and biomarker projects.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
REQUIREMENTS:
The Scientist - Immunoassay and Biomarker Development's primary focus is on immunoassay development, screening, and biomarker projects.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Assist in ligand binding assay method development (MSD, ELISA) and provide technique and application support for immunoassays transferred to downstream users.
- Test antibody quality for purity (SDS-PAGE), specificity (Western Blot, ELISA), and concentration (Nanodrop, BCA).
- Conduct assay performance validation.
- Conduct compound screening utilizing the developed assays.
- Develop pharmacodynamic biomarker assays to support internal clinical development.
- Perform protein analysis (SDS/native-PAGE, Western Blot, and Immunoprecipitation).
- Develop experiment protocols and prepare SOPs.
- Perform and manage cell culture experiments for MOA, PD biomarker mechanistic insight, as well as biomarker assessment.
- Perform laboratory experiments carefully and troubleshoot to solve problems.
- Meticulously document experiment results in laboratory notebooks and databases timely.
- Analyze, summarize, and present experimental results to managers and other team members.
- Prepare experiment and project reports as required.
- Order and stock laboratory supplies for a continuous and consistent workflow.
- Other duties, as assigned.
REQUIREMENTS:
- Requires a PhD (1-3 years' experience) or MS (4-7 years) in biology/biochemistry/chemistry/immunology.
- Knowledge and prior experience with protein analytical methods, such as ELISA, Protein concentration assays, SDS-PAGE, Western Blot and mass spectrometry (a plus).
- Prior experience managing cell culture experiments for MOA and biomarker assessment.
- Qualified applicants must have good pipetting skills, be analytical, and flexible.
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