Overview

Monte Rosa Therapeutics is seeking a motivated HighThroughput Ceelular Assasy expert to contribute to our mission of eliminating disease-causing proteins through targeted protein degradation, an innovative approach that enables us to target proteins once considered undruggable. The ideal candidate will have strong expertise in developing high-throughput cellular assays for screening and compound profiling. You will join a fast-paced and innovative team environment that values teamwork, collaboration, and scientific rigor.

Responsibilities

• Culture a variety of cell lines and primary cells to develop and optimize high-throughput cellular assays to evaluate target engagement, degradation and pathway modulation
• Utilize automation system to execute cell-based screening and profiling campaigns
• Collaborate within a matrixed environment that integrates multiple functions to drive program decisions.
• Keep meticulous records of experiments on ELN.

Qualifications

• MS or Ph.D. with in Molecular Biology, Biochemistry, Biology, or related field.
• The Senior Research Associate II level will have 4-6 years of relevent industrial experience and a Scientist wiill pocess 1-2 years industrial exerience

• A thorough understanding of assay principles is required
• Hands-on experience developing and executing cellular assays for lead discovery and optimization is required. Relevant assay formats include NanoBRET, cellular HTRF, AlphaLISA, HiBiT, and NanoBiT, Degradation Kinetics.
• Experience working in a drug discovery environment is preferred.

• Experience with compound screening formats, laboratory instrumentation and automation, data analysis and management is preferred.
• Strong collaborative mindset with the ability to thrive in a team-oriented setting.

• Ability to adapt effectively to rapidly approaching deadlines in a dynamic research environment.
• Excellent oral and written communication skills.