Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines’ Cancer Biology group is looking for a talented, creative, and motivated scientist with a strong background in chemical biology, biochemistry, and cell biology to support early target discovery, screening, and validation efforts for novel oncology programs. The successful applicant will join the Chemical Biology and Proteomics team within Discovery Biology. They will work in a cross-functional team with chemists, cell, and structural biologists and utilize a wide array of molecular biology, biochemical and cellular assays to identify and validate novel targets for RevMed’s unique molecular glue platform. They will help inform and support high-throughput screening efforts and work closely with the mass spectrometry team to support MS-based proteomics workflows. The ideal candidate will have hands-on experience with a number of biochemical and cellular assays, expertise in assay development and troubleshooting, as well as a strong background in cancer biology and novel oncology targets. Above all, we are looking for a highly motivated and driven team player to join our diverse and talented team of scientists at RevMed.

Responsibilities:

• Design, execute, and troubleshoot biochemical and cellular assays for novel oncology targets
• Stay on top of relevant literature to identify novel target opportunities
• Work with HTS team to conduct, analyze and follow up on biochemical and cellular screens
• Perform mechanistic studies as part of hit validation efforts
• Collaborate cross-functionally with biology, biochemistry, chemistry and structural biology colleagues at RevMed
• Manage projects at external CROs
• Generate data in a timely manner and maintain detailed experimental records
• Regularly and effectively communicate findings at project team and company meetings

Required Skills, Experience and Education:

• PhD in chemical biology, biochemistry, or related discipline plus 5 years of relevant industry experience
• Hands-on experience culturing, manipulating and characterizing mammalian cells: cell culture, viral transduction, CRISPR/Cas9 gene editing, viability and mechanistic assays
• Experience with standard molecular biology and biochemistry assays, including characterizations of covalent target engagement
• Experience interrogating PPIs, including proximity labeling
• Ability to drive projects and work independently
• Strong problem-solving skills with sound technically driven decision-making ability
• Effective written and verbal communication skills as well as interpersonal skills
• A creative team-player with capacity to be effective in a dynamic company environment

Preferred Skills, Experience and Education:

• Hands-on experience with cellular and phenotypic screens (genetic or pharmacological), hit finding and validation
• Knowledge of molecular glues and similar modalities
• Solid background in cancer biology and cancer-relevant pathways (both tumor-cell intrinsic and extrinsic), novel oncology targets
• Experience with large-scale data interpretation and visualization