Top 10 Most Innovative Medical Device Companies of 2025, According to Fast Company

Thanks to an unprecedented technology boom — driven by AI, robotics and data analytics — the medical device industry is reimagining patient care.

In March alone, several companies announced ongoing efforts, including Volition’s Nu.Q Cancer Test — a noninvasive, blood-based diagnostic that is being developed for early cancer detection; Korea-based NOUL’s miLab, a compact, bench-top AI-powered cervical cancer screening platform that delivers results in 15 minutes; Menarini’s collaboration with VisualDx, which leverages AI to more accurately detect rare blood cancers like blastic plasmacytoid dendritic cell neoplasm (BPDCN); and Steer Health’s launch of SteerConnect, the first AI-powered digital gateway designed to connect patients to personalized care.

Fast Company’s annual list has highlighted 10 trailblazers transforming treatments and diagnostics — whether by streamlining surgeries, enabling remote monitoring or making therapies less invasive.

Below are 10 most innovative medical device companies setting new standards for invention in 2025.

HistoSonics

HistoSonics’ Edison Histotripsy System, recently featured in a Reuters Global Health documentary, shows promise for noninvasive tumor treatment. The GANNON trial is studying its safety and efficacy in treating pancreatic tumors, while the BOOMBOX master study is assessing its broader use in various solid tumors.

Heartflow

Heartflow combines advanced computed tomography imaging with AI-driven analysis. Its flagship service, Heartflow One, creates personalized 3D models of patients’ coronary arteries to noninvasively assess blood flow and plaque burden. Recently, the company partnered with NFL alumni and Boone Heart Institute to launch the GameFilm Registry, which aims to assess heart disease risk in retired football players.

ROMTech

ROMTech developed PortableConnect, a telemedicine rehabilitation cycle designed to support patient recovery — especially for veterans. The system connects patients with clinicians through a custom app and wearable tracking. This approach reduces costs and improves access to effective physical therapy.

Xenco Medical

Xenco Medical is redefining spinal surgery and recovery with its TrabeculeX Continuum. This solution combines a bioactive matrix that promotes bone regeneration with a digital recovery app for remote patient monitoring. Additionally, Xenco has expanded its clinical adoption globally, including in South Korea. The company was named to Fast Company’s Most Innovative Companies list for the second time.

SprintRay

SprintRay is transforming dental 3D printing. The company integrates AI-assisted design software with rapid, precise printing hardware. This enables dental practices to produce crowns, dentures and other appliances in-house, cutting turnaround times and enhancing restorative accuracy.

Cala Health

Cala Health’s wearable device, Cala kIQ, uses transcutaneous afferent patterned stimulation (TAPS) to treat essential tremors. The company closed an oversubscribed $50 million financing round to fuel growth and expand market reach. This supports further scaling of Cala kIQ and reinforces its role in neuromodulation therapies.

Medtronic

Medtronic recently earned FDA approval for the world’s first adaptive deep brain stimulation system for Parkinson’s, which offers personalized adjustments for patients. Additionally, clinical trial data show that the Evolut transcatheter aortic valve replacement (TAVR) system delivers superior valve performance in patients with narrower aortic annuli — providing a more effective treatment option.

Virtual Incision

Virtual Incision’s MIRA surgical system, a miniaturized robotic-assisted device, became the first surgical robot tested aboard the International Space Station. In collaboration with NASA and the University of Nebraska, spaceMIRA was remotely operated from Earth to simulate surgical tasks in zero gravity, exploring its potential for long-distance remote procedures.

Additionally, Virtual Incision is exploring NVIDIA ISAAC, an advanced robotics development platform, to enhance MIRA’s precision and real-time responsiveness in the operating room.

Bruin Biometrics

Bruin Biometrics tackles the challenge of detecting bedsores early with its Provizio SEM Scanner. This scanner uses high-resolution scanning and AI-powered analysis to capture detailed tissue views for early disease detection. By providing rapid, accurate diagnostic data, the system enhances clinical decision-making and patient care. In 2024, Bruin Biometrics was honored with the prestigious Pinnacle Healthcare Diamond Award 2025.

Elixir Medical

Elixir Medical’s DynamX bioadaptor is an adaptive implant designed to restore natural vessel function following angioplasty. Unlike conventional stents, DynamX allows the treated vessel to remain flexible over time. Six-month study data indicate that DynamX shows favorable performance in patients with acute coronary syndrome and complex lesions, demonstrating improved vessel healing and function.