Top 15 Most Innovative Healthcare Companies of 2025, According to Fast Company

In 2024, the healthcare industry made significant waves — TIME spotlighted Laguna Health for its AI-powered patient-care platform, while The Healthcare Technology Report recognized 50 trailblazing women leading progress in digital health, AI and medical devices. AI also gained traction across the sector, with UK-based home healthcare company Cera earning a Health Tech Digital Award for its advanced AI tools that support clinical decision-making and enhance home care efficiency.

In this Xtalks blog, take a look at the top 15 most innovative healthcare companies — recognized by Fast Company in 2025 — for their work in clinical documentation, inclusive care, women’s health, diagnostic testing and more.

Abridge

Abridge offers an AI platform that converts clinical conversations into billable documentation. Recently, Memorial Sloan Kettering Cancer Center expanded its use in oncology, noting effective capture of complex terminology in languages such as Spanish, Chinese and Russian.

Babson Diagnostics

Babson Diagnostics, partnering with BD, has introduced BetterWay Blood Testing — a fingertip collection method that requires a significantly smaller blood sample, enhancing patient comfort and accessibility. Recently recognized as an SXSW Innovation Awards finalist in the Health & Biotech category, it is supported by extensive clinical studies.

Knownwell

Knownwell is expanding its national presence by unveiling six new clinics in the Greater Chicago area. The company is also partnering with LillyDirect to broaden access to independent, comprehensive metabolic care options across the US. These initiatives aim to provide inclusive, patient-focused weight management care.

AISAP

AISAP develops an AI-powered point-of-care ultrasound platform for cardiac diagnostics. Partnering with Amavita Heart and Vascular Health, AISAP CARDIO has been deployed in underserved Florida communities to screen for valvular diseases, including aortic stenosis. Its cloud-based solution connects with electronic health records and telemedicine systems, aiding early detection and improved outcomes.

WellRithms

WellRithms applies advanced AI analytics to ensure billing accuracy and reduce overpayments. Last year, the company launched Comp42, a new suite of payment integrity services designed to streamline workers’ compensation bill reviews and expedite dispute resolution.

Paragonix Technologies

Paragonix Technologies has advanced organ preservation with its KidneyVault system, which maintains renal viability during transport using a novel perfusion solution. Recently, the world’s first in-human use for it was announced, followed by Vanderbilt Health’s first successful kidney transplant using this technology.

SCAN Group

Focused on tailoring Medicare plans to meet the needs of diverse communities, SCAN Group offers culturally sensitive care that ensures relevant and accessible services. The company also recently invested in League, a digital health platform, to launch a mobile-first member experience that enhances communication and care coordination.

Midi Health

Midi Health is a virtual clinic focused on delivering insurance-covered care for women navigating menopause and midlife transitions. Last year, it collaborated with Mount Sinai Health System to expand expert menopause care in the New York City area. Midi Health also launched a dedicated survivorship program for women with a personal or family history of breast cancer.

Bend Health

Bend Health provides virtual mental health services for children and young adults. Recognized by Fortune as the best overall online therapy for kids in 2024, the company also launched Psych Urgent Care, offering 48-hour mental health support for youth, thereby expanding access to timely care for children and adolescents.

Nest Health

Nest Health provides a model of care that brings medical, social and behavioral support directly to patients’ homes. Moreover, Inc. recently recognized Nest Health’s female founders on its 2025 Female Founders 500 List, highlighting their leadership and innovative approach to reducing hospital utilization and improving outcomes for high-risk families.

Curative

Curative’s innovative health insurance solution removes copays and deductibles through its Zero Card. Curative partnered with Rula Health, a digital behavioral health platform, to offer $0 mental health services to its members nationwide. Eligible members can access therapy and psychiatry services with no copays or deductibles.

Homeward Health

Homeward Health connects rural patients with local healthcare providers through its navigation platform. The company launched its American Rescue Plan Act (ARPA) program to secure critical funding for expanding rural care infrastructure and enhancing community partnerships. Additionally, Homeward Health’s co-founder was also recognized on Inc.’s 2025 Female Founders list.

Apella

Apella employs AI and computer vision to enhance operating room safety and efficiency. At Tampa General Hospital, AI-powered insights streamlined scheduling and real-time patient monitoring, reducing delays. Meanwhile, Houston Methodist Hospital reported significant efficiency gains and improved resource utilization by integrating Apella’s technology into surgical workflows.

Infinitus Systems

Infinitus Systems automates routine administrative calls to reduce wait times and ease burdens on healthcare providers. A recent Series C funding round led by a16z supports further innovation, and a new application now seamlessly connects with electronic health records to simplify workflows and improve data access.

Freshpaint

Freshpaint is a privacy-first marketing analytics platform dedicated to helping healthcare marketers optimize ad spend. Its new Ad Performance solution links ad clicks to patient appointments, delivering full visibility into the patient journey. This tool enables the precise measurement of customer acquisition costs and ROI, while ensuring strict compliance with privacy regulations.