Adjudication Best Practices to Prevent Costly Trial Delays

Lessons from the Field with ICON

Endpoint adjudication can determine how smoothly a trial runs. When endpoints are clinical events, adjudicated outcomes are on the critical path for key decisions and timelines. Their impact spans the study, influencing enrollment targets in event-driven protocols, interim analyses, periodic safety assessments by Data Safety Monitoring Boards (DSMBs) and progress toward database lock. This webinar explores where adjudication most often breaks down and how field-tested practices can reduce cycle times to keep decisions on track.

Drawing on decades of hands-on trial experience, the featured speakers will highlight common operational failure points and practical approaches that improve endpoint reporting, case processing and adjudicator decision-making while maintaining quality. Attendees will also learn how adjudication outputs connect to interim analyses, safety oversight and database lock planning.

Register for this webinar to learn how adjudication best practices can streamline endpoint workflows and support timely trial decisions.

Speakers

Kristin Prusmack, Senior Director, Adjudication and DMC Management, ICON

Kristin Prusmack is the Functional Head of Endpoint Adjudication and Data Monitoring Committee Management at ICON, providing global leadership across vision, strategy, operational delivery and financial performance. She brings a deep background in adjudication and safety committee services, with a track record of leading teams, building client partnerships and ensuring projects are delivered to quality expectations, on time, and in compliance with sponsor SOPs and regulatory standards. Kristin began her career as a Registered Nurse in Cardiac Cath, Electrophysiology and Vascular Labs and has since built extensive expertise in cardiovascular-focused research and governance.

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Emily Trymbiski, Director DMC and Endpoint Adjudication, ICON

Emily Trymbiski is a Clinical Research Leader with 15+ years of endpoint adjudication experience spanning procedure development, event identification and delivery of high-quality, regulatory-compliant trial documentation. In her current role as a Director at ICON, she provides oversight and leadership across endpoint adjudication and data monitoring committee projects, supporting sponsors from proposal and bid defense through service delivery and closeout. Emily is known for building efficient, audit-ready processes, mentoring cross-functional teams and driving consistent execution across global, high-profile trials.

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Catherine Tyner, Head of Clinical Strategy, AG Mednet

With 28 years of clinical research experience, Cathy Tyner has led multiple functional departments including clinical safety, 24×7 medical monitoring coordination, vendor management and oversight group management (which encompasses the coordination of clinical endpoint, data, eligibility and monitoring committees, core laboratories and other expert panels). Cathy has overseen the delivery of more than 500 clinical trials, including complex megatrials across diverse therapeutic areas. She has made significant contributions to industry thought leadership and best practice guidance throughout her career. Cathy is a seasoned senior business leader who is dedicated to delivering strategic insights and practical, creative solutions in the clinical trial space.

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