Creating Digital Biomarkers with Real-World and Existing Data

Dr. Daniel R. Karlin, MD, MA, Chief Medical Officer, MindMed

Dr. Daniel R. Karlin joined MindMed as Chief Medical Officer in February 2021 following MindMed’s acquisition of HealthMode, the company he co-founded and led as CEO.

Prior to HealthMode, Dan built and led clinical, informatics and regulatory strategy for Pfizer’s Digital Medicine and Innovation Research Lab. He also served as Global Clinical Lead for psychiatry clinical compounds at Pfizer. He previously served as the Founder and Chief Medical Officer at Column Health, a leading technology-enabled psychiatry and addiction practice. He is a strategic advisor to several pharmaceutical, biotech and health technology companies. He is also a founding Advisor to the Digital Biomarkers Journal, Founder and Board Member, Digital Medicine Society (DiMe), and is on committee Leadership Digital Drug Development Tools at Critical Path Alzheimer’s Disease, MJFF and Mental Health IT at the APA.

Dan is board-certified in psychiatry, addiction medicine and clinical informatics. He is an Assistant Professor of Psychiatry at Tufts University School of Medicine. He graduated with degrees in neuroscience and behavior (BA), and clinical informatics (MA), Columbia University; Medicine (MD), University of Colorado School of Medicine.

Dr. James Connolly, Lecturer in Computing at Atlantic Technical University, Co. Donegal, Ireland

Dr. James Connolly is an experienced lecturer and researcher with a demonstrated history of working in the higher education industry. He is skilled in digital healthcare and connected health, big data analytics and artificial intelligence. Dr. Connolly is a strong education professional with a Doctor of Philosophy (PhD) focused on a combination of wearable technology and computing from Ulster University.

Dr. William Crown, Distinguished Scientist at Brandeis, The Heller School for Social Policy and Management

Dr. William Crown is a Distinguished Research Scientist in the Heller School. He is an internationally recognized expert in real-world data analysis, focusing upon research designs and statistical methods for drawing causal inferences from transactional health care datasets such as medical claims and electronic health records. Bill began his career at the Heller School in the early 1980s focusing on the demography and health economics of aging and taught a series of statistics courses in the Heller PhD program. He left Brandeis in the mid-1990s to lead health economics consultancies at Truven and Optum. From 2013-2020, he was Chief Scientific Officer at OptumLabs where he provided methodological guidance on a portfolio of research projects with specific focus on causal inference in database studies, simulation of health care systems and application of operations research methods to health policy questions.

He received his doctorate degree in regional economic modeling from the Massachusetts Institute of Technology, and a Master of Arts in Economics from Boston University. He has an extensive record of empirical comparative effectiveness studies and methodological publications in clinical and health policy journals. Dr. Crown was the President of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) between 2013-14. He currently co-chairs the ISPOR Task Force on Machine Learning and is particularly interested in the intersection of machine learning and causal inference methods, as well as transparency in the conduct and reporting of empirical health care research.

(Moderator) Geoff Gill, President, Shimmer Research Inc.

Geoffrey Gill is the President of Shimmer Americas. He is the Founder of the Verisense Digital Health Panel, which is creating a large, longitudinal database of raw digital sensor data, patient-reported outcomes and real-world data. He is also a Co-Founder of the Open Wearables Initiative.