Expediting Dry Powder Inhaler Formulation Development Through Modelling and Advanced Characterization

Drug Discovery and Development, Life Sciences, Pharma Manufacturing and Supply Chain, Pharmaceutical,
  • Tuesday, December 04, 2018

Dry powder inhalers are gaining increasing momentum for drug delivery to the lungs. One of the most used and flexible delivery technologies are capsule-based dry powder inhalers.

The successful development of a dry powder inhaler formulation is strongly influenced by the choice of excipient and the ratios between the excipient and active pharmaceutical ingredient (API). The rheological behavior of the powder mixture and its microstructure have a significant impact on several aspects of the final product, such as content uniformity and stability of the formulation, overall aerodynamic performance, deposition patterns and also on the robustness and effectiveness of the capsule filling process.

The present webinar focuses on development by design strategies for dry powder inhalation products. Critical development parameters for an integrated design space analysis will be discussed, showing the compromise between different parameters of performance and downstream process. Moreover, the incorporation of novel characterization strategies such as dissolution and microstructure analysis will be explored.

Speakers

Beatriz Fernandes, PhD, Scientist DPD, Hovione

Beatriz Fernandes joined the R&D Drug Product Development group at Hovione in 2018 where she has been working on particle design and formulation development projects, with particular focus on the area of inhalation drug products.

Beatriz has an academic background in biological engineering, holding a Master’s degree in Biological Engineering from University of Lisbon, Instituto Superior Técnico. Currently, she is finishing an Industrial PhD in Pharmaceutical Technology in a joint collaboration between the Faculty of Pharmacy from University of Lisbon and Hovione SA. Her PhD thesis is focused on the development of in vitro dissolution techniques for evaluation of inhalation products.

Her research also embraced the investigation of advanced characterization techniques applied for the development of inhalable particles.

Message Presenter

Eunice Costa, Group Leader Inhalation, R&D Drug Product Development, Hovione

Eunice Costa joined the R&D Drug Product Development group at Hovione in 2011 and has been since then working on particle design and formulation development, particularly for Inhalation drug products. At Hovione, she has also been the scientific advisor for PhD programs in inhalation and biopharmaceuticals. Eunice holds a PhD in Bioengineering Systems from the MIT-Portugal Program that integrated polymer chemistry, materials characterization and tissue engineering. Before pursuing her PhD, Eunice worked as a researcher in different institutions such as the Early Stage Pharmaceutical development group at Genentech, USA, as well as on the Human Physiology department at TNO, The Netherlands.

Message Presenter

Who Should Attend?

Scientists working in the inhalation field from pharmaceutical, biotechnology and chemical companies, plus academia

What You Will Learn

  • Fundamentals of drug product development for inhalation
  • Development by design strategies to expedite the development of dry powders for inhalation.
  • Dissolution techniques as an in vitro test during dry powder inhaler development
  • Advanced strategies in dry powder inhaler characterization

Xtalks Partner

Hovione

Hovione has almost 60 years of experience as a Specialist Integrated CDMO offering customized services and innovative solutions from drug substance to drug product, with all activities performed at the same site, providing a fully integrated service for clinical and small commercial scale complex drug product development and manufacturing. As the Leader in Commercial Spray Drying, Hovione can handle projects from development to market. Our particle engineering technologies can address challenges in solubility enhancement, lung delivery, modified release and taste-masking applications and can handle highly potent compounds. Hovione also offers integrated inhalation development services. We do well what is difficult, to give our customers what they cannot find elsewhere. Please visit www.hovione.com.

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