Poorly water-soluble active pharmaceutical ingredients (APIs) pose one of the most common challenges in drug product development today. Over half of marketed APIs and as many as 90 percent of new drug candidates suffer from solubility challenges, limiting their therapeutic effect and hindering innovation. While there are solubility-enhancing techniques and excipients available, traditional options often suffer from poor effectiveness, complex manufacturing, or negative patient side effects.
Lubrizol Life Science Health (LLS Health) has developed safe, novel excipients for improving the solubility of oral and injectable drug products.
In this webinar, the featured speakers will introduce two patented, solubility-excipients: Apinovex™ Polymers for oral amorphous solid dispersions and Apisolex™ Polymers for injectable formulations.
The featured speakers will explain how these polymers enable scalable, reproducible manufacturing of drug products and present case study data on solubility enhancement. Webinar attendees will also learn how Apinovex and Apisolex polymers enable intellectual property (IP) protection and lifecycle management with 505(b)(2) filings.
Join this webinar to learn how these solubility-enhancing excipients enable efficient delivery of Biopharmaceutical Classification System (BCS) Class II and IV compounds for oral and injectable drug products.
Nick DiFranco, Global Market Segment Manager for Oral Treatments, Lubrizol Life Science Health
Nick DiFranco, MEM, is the Global Market Segment Manager for Oral Treatments at Lubrizol Life Science Health (LLS Health). In his role, Nick coordinates a multi-disciplinary team offering excipients and services for controlled release and solubility enhancement in oral solids and liquids, including Carbopol® and Apinovex™ polymers. Prior to this role, Nick held positions as an Applications Scientist and Market Manager at Lubrizol supporting long-acting drug delivery and CDMO services. Nick holds a BS in Biomedical Engineering (Biomaterials focus) and a Master of Engineering and Management degree from Case Western Reserve University.
Joey Glassco, Senior Global Market Manager for Parenteral Drug Delivery, Lubrizol Life Science Health
Joey Glassco, MBA, is the Senior Global Market Manager for Parenteral Drug Delivery at Lubrizol Life Science Health (LLS Health). Joey has served as Marketing Director for CDMO division since 2017 and has been involved in pharmaceutical excipient new business development since 2013. Prior to joining the LLS Health, she spent nearly 15 years in marketing roles in various Lubrizol business units. Joey also has over 10 years of experience in finance at Lubrizol, Ford Motor Company, and The Franklin Mint. She received Bachelor of Science degrees in Finance and Accounting from Juniata College and her MBA from the Smeal College of Business at Pennsylvania State University.
Liliana Miinea, Technology Manager for Pharmaceutical Excipients, Lubrizol Life Science Health
Liliana Miinea, PhD, is a Technology Manager at Lubrizol Life Science Health (LLS Health). Her work focuses on developing new technologies for pharmaceutical applications mainly in the area of controlled release, drug solubility enhancement and enhanced mucosal delivery. She has over 20 years of experience in developing and characterizing ingredients including nanomaterials, polymer/nanomaterials composites, and novel excipients. Prior to Lubrizol she worked at Avantor Inc., NJ and conducted postdoctoral research at Washington University in St. Louis, and Center for Nanomaterials Research at Dartmouth College, USA. Liliana holds a PhD in Chemistry from the University of Houston, TX.
Who Should Attend?
Members of the pharmaceutical industry interested in solubility enhancement and/or 505(b)(2) product development, including:
- Formulation Scientists
- R&D/Technology Managers
- Chemistry, Manufacturing and Controls (CMC) Managers
- Business Development Professionals (New Chemical Entities [NCEs] and 505(b)(2)s)
- Strategic Alliance/Partnership Managers
What You Will Learn
Register for this webinar to learn:
- Solubility and bioavailability enhancement techniques for BCS Class II and IV APIs
- How oral-grade Apinovex™ Polymers enable stable, amorphous solid dispersions with up to 80% drug loading
- How injectable-grade Apisolex™ Polymers can increase solubility by up to 50,000 times where other excipients fail
- Case study data comparing Apinovex and Apisolex polymers to other solubility-enhancing excipients
- The use of novel excipients to enable IP protection and 505(b)(2) products
Lubrizol Life Science Health
Lubrizol Life Science Health (LLS Health) specializes in helping clients from idea to execution by offering innovative polymers and excipients, as well as best-in-class contract manufacturing services. LLS Health is one of the world’s largest manufacturers of pharmaceutical grade carbomers, polycarbophil, and thermoplastic polyurethanes (TPU), and has been manufacturing pharmaceutical excipients for more than 40 years. With this longstanding history of polymer proficiency and continued investment in cutting-edge technologies and equipment, we are a sustainable partner prepared to meet your needs and enable the development of patient-centric solutions.