Revolutionizing Biomarker Development: Automated Detection and Isolation of Extracellular Vesicles

In this webinar, the expert speakers will discuss a one-step automated method for affinity-specific detection, quantification and isolation of extracellular vesicles for downstream analysis, which would lead to unbiased and reproducible development of extracellular vesicle-based biomarkers in disease and therapy research.

Specific detection, quantification and isolation of extracellular vesicles is a particularly challenging task due to the heterogeneity of extracellular vesicles and the complexity of matrices in which they are typically found such as culture medium or blood plasma. The analytics for extracellular vesicles combined with liquid biopsy could lead to earlier diagnosis and stratified treatment that will save lives (e.g. cancer mortality reduction by 20-25 percent) and lower the healthcare burden cost (>5 percent reduction).

However, current methods to purify and quantify extracellular vesicles take a long time, introduce a bias and are costly and imprecise, thereby hampering progress in the research and development related to extracellular vesicles. However, the lack of methods to characterize the whole extracellular vesicle directly in crude samples restricts clinical sensitivity in diagnostics.

The expert speakers will be discussing a breakthrough label-free fiber-optic method in an automated platform for biomolecular sensing. This method combines affinity-based quantification with simultaneous affinity isolation or downstream analysis.

This integrated solution using a sensor dip-in probe is a new, selective, automated (scalable), fast (hours) and specific (purity up to 95%) method to accurately quantify and isolate extracellular vesicles directly from cell culture supernatant and plasma samples. Proof of concept data will be presented to demonstrate yield for downstream analysis and for specific capture of circulating neuronal tissue extracellular vesicles from human plasma.

Register for this webinar to learn how research studies and analysis workflows can become more efficient and effective from one-step immunospecific analytical isolation and collection of biologics, exosomes and extracellular vesicles or even of cells in suspension.

Speakers

Dr. Aida Montserrat Pagès, PhD, Scientist, FOx BIOSYSTEMS

Dr. Aida Montserrat Pagès is a bionanotechnology researcher with a passion for developing cutting-edge biosensors. She is currently working on assay development for the detection and analytical isolation of extracellular vesicles with fiber optic sensors. She holds a PhD in Bioscience Engineering from KULEUVEN. She worked on DNA enzymes and then worked on biosensors as a postdoctoral researcher at KULEUVEN.

As a visiting PhD student at the University of Oxford in the lab of Prof. Achillefs Kapanidis, she studied single-molecule sensing methodologies. Her prior education includes an MSc in Advanced Nanoscience and Nanotechnology from the Universitat Autònoma de Barcelona.

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Dr. Ryan Pink, PhD, Reader in Molecular Biology and Genomics, Oxford Brookes University; CEO, MetaGuideX

Dr. Ryan Pink is the CEO of MetaGuideX, Biomedical Researcher, Commercial Consultant and Reader who is pursuing a successful and creative career on the cutting edge of biotech, life sciences and healthcare.

As a Reader in Molecular Biology and Genomics, he manages a research group that covers cancer biology and cell development, focusing on exosomes and omic analysis. He is involved in cross-institute collaboration. At MetaGuideX, he is driving the development of cost-effective, novel, early cancer diagnostics.

As a Board Member of the UK Society of Extracellular Vesicles, he supports the development of extracellular vesicle education and research across the UK. His prior roles include consulting for life sciences products, industrial development, Oxford Academic Health Partners, Oxford Academic Health Science Centre and TheHill. He holds a PhD in Cell Biology of Cancer from Cranfield University.

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