Automation of Solid-Phase Aromatic Foldamer Synthesis
About this webinar
The synthesis of long helical oligoamide foldamers composed of more than 20 aromatic monomers of 8-amino-2-quinoline carboxylic acid can now be routinely achieved by using an in lab-developed solid-phase foldamer synthesis (SPFS) methodology that relies on acid chloride activation.
The automation of the SPFS conditions is revolutionizing the production of high molecular weight aromatic oligoamides with very good yield and purity and faster production compared to the manual approach. That constitutes a critical milestone in the field of aromatic foldamer chemistry with many concrete applications such as the modulation of protein-protein interactions in competitive research programs.
Register for this webinar to learn more on aromatic oligoamide foldamer (AOF) chemistry, automated parallel solid-phase foldamer synthesis on the PurePep® Chorus synthesizer — a next-generation, multi-scale peptide synthesis platform — and other applications.
Who should attend
- Scientists, Senior Scientists
- Technical Leaders
- Peptide and Bioorganic Chemists
- PhD Candidates, Post-Doctoral Researchers
- Researchers interested in foldamer chemistry, developing new solid-phase methodologies, automation, protein-protein interactions
What you will learn
- Efficient and reliable coupling methodologies which remain very remote from conventional peptide coupling approaches on the solid phase
- A next-generation, multi-scale peptide synthesizer platform and a special focus on how this platform can be diverted from its initial application to meet the needs of a growing field of research — foldamer chemistry
Featured Speakers
Dr. Céline Douat, PhD
Dr. Céline Douat was trained as a Peptide Chemist at the University of Montpellier I, France, and received her PhD in drug science in 2001. After several post-doctoral positions where she, among other subjects, worked on catalytic peptide dendrimers with Prof. Jean-Louis Reymond at the University of Berne (Switzerland), she was appointed CNRS researcher at the University of Bordeaux (France) in 2006. She then refocused her research activity on peptidomimetic foldamers, specifically on helical oligoureas in the group of Dr. Gilles Guichard. In 2017 she moved to the department of pharmacy at the LMU (Munich, Germany) as the Chair of Chemical Biology with Prof. Ivan Huc, where she implemented the automation of aromatic foldamer solid-phase synthesis.
Partner for this event
Gyros Protein Technologies
Gyros Protein Technologies enables peptide synthesis and bioanalytical solutions that help scientists increase biomolecule performance and productivity in research, drug discovery, pre-clinical and clinical development, and bioprocess applications. Our low to mid-scale peptide synthesizer platforms are the PurePep® Chorus, Symphony® X, and PurePep® Sonata®+. These solutions and our chemistries deliver uncompromising purity, flexibility, and quality for discovery and pre-clinical studies of simple to complex multifunctional peptides. Proprietary high performance nanoliter-scale immunoassay platforms, Gyrolab® xPand, Gyrolab® xP workstation and Gyrolab xPlore(tm), are used by scientists in leading pharmaceutical, biotech, CRO, and CMO companies for bioanalytical applications such as pharmacokinetics/pharmacodynam
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