Assuring that a stable cell line originates from a single progenitor cell is a fundamental component of the development of protein, cellular and gene therapies. However, monoclonality assurance is often a rate-limiting step in cell line development, leading to project delays and increased risk.
In this webinar, the featured speaker will provide an overview of an end-to-end workflow that not only achieves 99.99% probability of clonality but also digitalizes and automates the process of generating evidence of clonality for IND submissions.
Attendees will gain actionable insights into minimizing ghost well risk with high-efficiency single-cell seeding. The speaker will share an overview of how to achieve a workflow that generates a probability of clonality of over 99.99% in combination with a clonal imager, without sacrificing throughput or efficiency with an AI-powered data management suite.
Join this webinar to discover practical strategies for improving monoclonality assurance, reducing ghost well risk and generating stronger evidence of clonality from Day 0.
Speaker
Adam Causer, Global Product Manager, Solentim Portfolio, Nova Biomedical
Adam Causer is a Global Product Manager for the Solentim Portfolio at Nova Biomedical, which includes an ecosystem of instruments that digitalize and automate CLD workflows. Prior to starting this role, he worked in application sciences at both Scienion and Advanced Instruments, specializing in precision dispensing and single-cell isolation for diagnostic test development and CLD, respectively.
Adam’s early career included being a postdoctoral researcher that oversaw the day-to-day management of Cancer Research UK (CRUK), National Institute for Health Research (NIHR) and university-funded research projects. For these projects, he used a combination of basic science and physiological techniques to investigate the benefits of exercise on health, disease and pharmaceutical treatments. These techniques included cell culture, live cell imaging, flow cytometry, cell killing assays and multiplex protein quantification.
Message PresenterWho Should Attend?
This webinar is of value to:
- Scientists, Engineers and Lab Managers in CLD looking to integrate or expand automation
- Process Development staff in biotech companies and CDMOs seeking to improve or internalize cell line workflows
- Professionals driving scalable biologics development who aim to boost productivity and batch-to-batch consistency while reducing re-cloning cycles
- QA/Regulatory and CMC documentation owners building a stronger case for regulatory submissions
- Decision‑makers who want to future-proof CLD operations through strategic automation and analytics
What You Will Learn
Attendees will gain insights into:
- Why demonstrating clonality is critical to gene therapy manufacturing and how image-based documentation supports regulatory compliance
- How static culture conditions impact single-cell cloning in HEK293 lines adapted for suspension
- Strategies for improving clone outgrowth and resuspension in chemically defined systems
- Real-world data from feasibility studies evaluating single-cell workflows in bioproduction settings
- Best practices for preparing regulatory-ready clonality proof in forced-suspension cell lines
Xtalks Partner
Nova Biomedical
Advanced Instruments and Nova Biomedical are now doing business under the same brand, bringing together decades of expertise in analytical instrumentation, R&D, and global customer support. The Solentim® ecosystem is now part of Nova Biomedical’s portfolio, providing best-in-class imaging and single-cell deposition technologies for cell line development workflows and assurance of clonality for regulatory bodies.
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